Dipartimento di Chimica Organica Ugo Schiff, University of Florence, via della Lastruccia 13, 50019, Sesto Fiorentino, Florence, Italy.
Amino Acids. 2010 Jun;39(1):175-80. doi: 10.1007/s00726-009-0392-y. Epub 2009 Nov 26.
A simple approach to a new family of enantiomerically enriched polyunsaturated t-Boc-protected-delta-amino esters is described, via microwave promoted Stille coupling of (Z)-methyl-2-bromobutenoate with stannylated allylamines. The reaction conditions are mild and selective and disclose a simple way to 1-substituted butenoates of defined geometry.
描述了一种通过微波促进的（Z）-甲基-2-溴丁烯酸与锡化烯丙胺的 Stille 偶联反应，来制备新型对映体富集的多不饱和叔丁氧羰基保护的δ-氨基酸酯的简单方法。该反应条件温和且具有选择性，并揭示了一种制备确定几何形状的 1-取代丁烯酸酯的简单方法。
