Feldkamp J
Medizinische Klinik I, Klinikum Bielefeld.
Dtsch Med Wochenschr. 2009 Dec;134(49):2504-9. doi: 10.1055/s-0029-1243053. Epub 2009 Nov 25.
Autoimmune thyroiditis (AIT) is an autoimmune disease with genetic background. Women are more likely to develop AIT. In adulthood, AIT is the most frequent cause for acquired hypothyroidism. Cytotoxic T-lymphocyte antigen (CTL-4) may play a role in the etiology of the disease. Diagnosis is made by determination of elevated antibodies against thyroid peroxidase and thyroglobulin, and a hypoechoic pattern in ultrasound. In case of hypothyroidism a substitutive therapy with levothyroxine is necessary. AIT may occur as postpartum thyroiditis or as a special entity as consequence of therapy with cytokines.
自身免疫性甲状腺炎(AIT)是一种具有遗传背景的自身免疫性疾病。女性更易患AIT。在成年期,AIT是获得性甲状腺功能减退最常见的病因。细胞毒性T淋巴细胞抗原(CTL-4)可能在该疾病的病因中起作用。通过测定甲状腺过氧化物酶和甲状腺球蛋白抗体升高以及超声下低回声模式来进行诊断。若出现甲状腺功能减退,需用左甲状腺素进行替代治疗。AIT可表现为产后甲状腺炎,或作为细胞因子治疗的一种特殊后果出现。