美学心脏病学：脂肪来源干细胞在心肌修复中的应用。
Aesthetic cardiology: adipose-derived stem cells for myocardial repair.
机构信息
Department of Integrative Biology & Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.
出版信息
Curr Stem Cell Res Ther. 2010 Jun;5(2):145-52. doi: 10.2174/157488810791268654.
Stem cell biology has increasingly gained scientific and public interest in recent years. In particular, the use of stem cells for treatment of heart disease has been strongly pursued within the scientific and medical communities. Significant effort has gone into the use of adult tissue-derived stem cells for cardiac repair including bone marrow, blood, and cardiac-derived cell populations. Significant interest in this area has been balanced by the difficulties of understanding stem cells, cardiac injury, and the amalgamation of these areas of investigation in translational medicine. Recent studies have emerged on adipose-derived stem cells which show the potential for cardiac lineage development in vitro and may have application in cell-mediated in vivo therapy for the diseased heart. This review provides a summary of current findings within the field of adipose-derived stem cell biology regarding their cardiac differentiation potential.
近年来，干细胞生物学越来越引起科学界和公众的兴趣。特别是，科学界和医学界一直在大力研究利用干细胞治疗心脏病。人们已经投入大量精力研究利用成体组织来源的干细胞进行心脏修复，包括骨髓、血液和心脏源性细胞群体。该领域的研究兴趣非常大，但同时也面临着理解干细胞、心脏损伤以及将这些研究领域融合到转化医学中的困难。最近的研究表明，脂肪来源的干细胞具有体外心脏谱系发育的潜力，并可能应用于细胞介导的疾病心脏体内治疗。本综述提供了关于脂肪来源干细胞的心脏分化潜能的该领域的最新研究结果概述。
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