Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA 30912, USA.
Int J Neuropsychopharmacol. 2010 May;13(4):535-9. doi: 10.1017/S1461145709991015. Epub 2009 Nov 27.
Brain-derived neurotrophic factor (BDNF), which plays an important role in neurodevelopmental plasticity and cognitive performance, has been implicated in neuropsychopathology of schizophrenia. We examined the levels of both cerebrospinal fluid (CSF) and plasma BDNF concomitantly in drug-naive first-episode psychotic (FEP) subjects with ELISA to determine if these levels were different from control values and if any correlation exists between CSF and plasma BDNF levels. A significant reduction in BDNF protein levels was observed in both plasma and CSF of FEP subjects compared to controls. BDNF levels showed significant negative correlation with the scores of baseline PANSS positive symptom subscales. In addition, there was a significant positive correlation between plasma and CSF BDNF levels in FEP subjects. The parallel changes in BDNF levels in plasma and CSF indicate that plasma BDNF levels reflect the brain changes in BDNF levels in schizophrenia.
脑源性神经营养因子（BDNF）在神经发育可塑性和认知表现中起着重要作用，与精神分裂症的神经精神病理学有关。我们通过 ELISA 同时检测了未经药物治疗的首发精神病（FEP）患者的脑脊液（CSF）和血浆 BDNF 水平，以确定这些水平是否与对照值不同，以及 CSF 和血浆 BDNF 水平之间是否存在任何相关性。与对照组相比，FEP 患者的血浆和 CSF 中的 BDNF 蛋白水平均显著降低。BDNF 水平与基线 PANSS 阳性症状子量表的评分呈显著负相关。此外，FEP 患者的血浆和 CSF 中的 BDNF 水平之间存在显著的正相关。血浆和 CSF 中 BDNF 水平的平行变化表明，血浆 BDNF 水平反映了精神分裂症中大脑 BDNF 水平的变化。
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