[银杏内酯B柔性纳米脂质体的制备及经皮扩散]
[Preparation and transdermal diffusion of flexible nanoliposomes of ginkgolide B].
作者信息
Liu Ting, Zhen Xiaolong, Cheng Hao, Li Weize, Hao Baohua
机构信息
College of Life Science, Northwest University, Xi'an 710069, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2009 Sep;34(17):2181-4.
OBJECTIVE
To prepare flexible nanoliposomes of Ginkgolid B (GB) and study the transdermal diffusion law.
METHOD
Flexible nanoliposomes of GB were prepared by film dispersion method, and the shape and particle size of nanoliposomes were analyzed. GB permeation tests in vitro through the skin of rats were performed in modified Franz diffusion cell. The accumulated permeation amounts of GB alcoholic solution, flexible nanoliposomes of GB and ordinary nanoliposomes of GB were compared.
RESULT
The average encapsulation percentage, the particle size, and the Zata potential of the flexible nanoliposomes were (89.52 +/- 1.76)%, and was (208.3 +/- 25.49) nm, and was -49.2 mV, respectively. The accumulated permeation amount of flexible nanoliposomes in 8 hours was 189.97 microg x cm(-2), and its transdermal permeability in 8 hours was 23.75 microg x cm(-2) x h(-1).
CONCLUSION
The encapsulation percentage of the flexible nanoliposomes is good,and the stability of the GB nanoliposomes is fine. Flexible nanoliposomes can significantly enhance the diffusion rate of GB through the skin of rats.
目的
制备银杏内酯B（GB）柔性纳米脂质体并研究其透皮扩散规律。
方法
采用薄膜分散法制备GB柔性纳米脂质体，分析纳米脂质体的形态和粒径。在改良的Franz扩散池中进行GB体外透过大鼠皮肤的试验。比较GB醇溶液、GB柔性纳米脂质体和GB普通纳米脂质体的累积渗透量。
结果
柔性纳米脂质体的平均包封率、粒径和Zeta电位分别为(89.52±1.76)%、(208.3±25.49)nm和-49.2mV。柔性纳米脂质体8小时的累积渗透量为189.97μg·cm-2，其8小时的透皮渗透率为23.75μg·cm-2·h-1。
结论
柔性纳米脂质体的包封率良好，GB纳米脂质体的稳定性良好。柔性纳米脂质体可显著提高GB透过大鼠皮肤的扩散速率。
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