Dipartimento dell'Età Evolutiva, Clinica Pediatrica, University of Parma, Italy.
Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4 Suppl):17-22.
A review of SLIT studies reveals that both cumulative dose and maintenance schedules have widely varied between the published clinical trials. Pre-co-seasonal treatment for pollen allergy seems to be better than coseasonal treatment. There is a number of studies evaluating different durations of SLIT, but the heterogeneity of the study design, allergen extracts and outcome measures make it difficult to produce a meta-analysis on SLIT efficacy according to duration. Overall,duration of both the build-up phase and the maintenance treatment does not seem to influence the effectiveness of SLIT. This suggests that the quality of the extract is more important in determining the clinical response to SLIT than duration of therapy. Further studies are warranted to establish optimal duration of SLIT treatment.
一项 SLIT 研究综述显示，已发表的临床试验中，累积剂量和维持方案差异很大。花粉过敏的季节性前治疗似乎优于季节性治疗。有许多研究评估了 SLIT 的不同持续时间，但由于研究设计、过敏原提取物和结果测量的异质性，很难根据持续时间对 SLIT 疗效进行荟萃分析。总体而言，递增期和维持治疗的持续时间似乎不会影响 SLIT 的疗效。这表明，在确定 SLIT 治疗的临床反应方面，提取物的质量比治疗持续时间更为重要。需要进一步的研究来确定 SLIT 治疗的最佳持续时间。
