Interfaculty Institute for Biochemistry, University of Tuebingen, Hoppe-Seyler-Strasse 4, D-72076 Tuebingen, Germany.
Eur J Cell Biol. 2010 Feb-Mar;89(2-3):270-2. doi: 10.1016/j.ejcb.2009.11.007. Epub 2009 Nov 26.
Plants respond to outside stimuli by initiating signaling cascades that regulate gene expression. Little structural information is available on the signaling proteins that are part of the two-component systems of plants, and how changes in phosphorylation translate into alterations of three-dimensional structures and changes in recognition domains remains largely mysterious. Our work is on deciphering aspects of these systems through the crystallization and structural analysis of two-component system proteins in Arabidopsis thaliana.
植物通过启动信号级联反应来对外部刺激做出反应，从而调节基因表达。关于构成植物双组分系统的信号蛋白，以及磷酸化的变化如何转化为三维结构的改变和识别结构域的改变，我们所了解的信息很少。我们的工作是通过对拟南芥中的两种成分系统蛋白进行结晶和结构分析，来解析这些系统的各个方面。
