Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Am J Otolaryngol. 2010 Jan-Feb;31(1):67-9. doi: 10.1016/j.amjoto.2008.09.007. Epub 2009 Apr 23.
We report an episode of transient, severe hypertension occurring within 2 minutes of injection of 1% lidocaine with 1:100,000 U of epinephrine in a patient taking midodrine for orthostatic hypotension. We hypothesize that the patient's autonomic nervous system was dangerously susceptible to the effect of local anesthetic when combined with the vasoactive systemic effect of midodrine. Surgeons should minimize the use of vasoconstrictors in patients treated with midodrine to avoid hypertensive complications.
我们报告了一例患者在使用米多君治疗直立性低血压时，于 2 分钟内静脉注射 1%利多卡因和 1:100000 肾上腺素后出现短暂、严重高血压的病例。我们推测，当局部麻醉剂与米多君的全身血管活性作用结合时，患者的自主神经系统对其作用非常敏感。外科医生应尽量减少在使用米多君治疗的患者中使用血管收缩剂，以避免高血压并发症。
