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Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs.
Physiol Genomics. 2008 Sep 17;35(1):123-31. doi: 10.1152/physiolgenomics.90225.2008. Epub 2008 Jul 29.
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A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.
Nat Med. 2008 May;14(5):510-7. doi: 10.1038/nm1750. Epub 2008 Apr 20.
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Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes.
J Cardiovasc Pharmacol. 2008 Jan;51(1):106-10. doi: 10.1097/FJC.0b013e31815a958f.
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A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.
Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11288-93. doi: 10.1073/pnas.0509937103. Epub 2006 Jul 14.
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Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13020-5. doi: 10.1073/pnas.0405074101. Epub 2004 Aug 19.
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Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.
Nat Med. 2003 Oct;9(10):1300-5. doi: 10.1038/nm930. Epub 2003 Sep 14.
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An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study.
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Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.
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The myocardium-protective Gly-49 variant of the beta 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation.
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