X染色体失活：当剂量起关键作用时。

X chromosome inactivation: when dosage counts.

作者信息

Nora Elphège P, Heard Edith

机构信息

Institut Curie, CNRS UMR3215, INSERM U934, 75724 Paris Cedex 05, France.

出版信息

Cell. 2009 Nov 25;139(5):865-7. doi: 10.1016/j.cell.2009.11.009.

DOI:10.1016/j.cell.2009.11.009

PMID:19945374

Abstract

How do mammals count their X chromosomes and keep only one X active per cell? In this issue, Jonkers et al. (2009) show that Rnf12/RLIM, encoded by the X-linked gene Rnf12, induces X chromosome inactivation only when present above a certain threshold, a condition fulfilled when at least two Xs are active.

摘要

哺乳动物如何计算其X染色体数量并确保每个细胞中只有一条X染色体保持活跃？在本期杂志中，琼克斯等人（2009年）表明，由X连锁基因Rnf12编码的Rnf12/RLIM，只有在高于特定阈值时才会诱导X染色体失活，而当至少两条X染色体活跃时就会满足这一条件。