Institute of Pathology, Charité Universitätsmedizin Berlin, Germany.
Cancer Treat Rev. 2010 Feb;36(1):8-15. doi: 10.1016/j.ctrv.2009.10.005. Epub 2009 Nov 28.
Gene expression profiling studies and conventional approaches for the identification of genes involved in the initiation and progression of ovarian cancer have identified a plethora of potential therapeutic targets. This review summarizes the targets that show promise for specific interference in cancer cells, groups them according to their subcellular localization and involved biological processes and discusses their impact on experimental, pre-clinical and clinical therapy.
基因表达谱研究和传统方法鉴定卵巢癌发生和进展相关基因，已经确定了大量潜在的治疗靶点。本综述总结了具有特异性干扰癌细胞潜力的靶点，根据其亚细胞定位和涉及的生物学过程进行分类，并讨论了它们对实验、临床前和临床治疗的影响。
