Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Nanotechnology. 2010 Jan 8;21(1):015604. doi: 10.1088/0957-4484/21/1/015604. Epub 2009 Nov 30.
Surface-enhanced Raman spectroscopy (SERS) with enormous enhancements has shown great potential in ultrasensitive detection technologies, but the fabrication of large-scale, controllable and reproducible substrates with high SERS activity is a major challenge. Here, we report the preparation of Au nanoparticle arrays for SERS-active substrates with tunable particle sizes and interparticle gaps, and the enhancement factor of the SERS signal obtained from 4-mercaptopyridine probe molecules was as high as 10(7). The experimental data points show the increase of enhancement factor as a function of the ratio of diameter to interparticle gap, which can be explained by the averaged electromagnetic field enhancement model. Furthermore, we demonstrated that this type of substrate merits its high uniformity, high reproducibility and excellent long-term stability. As the fabrication protocol of such a SERS substrate is simple and inexpensive, this substrate may anticipate a wide range of applications in SERS-based sensors.
表面增强拉曼光谱（SERS）具有巨大的增强效应，在超灵敏检测技术中显示出巨大的潜力，但制备具有大规模、可控和可重复的高 SERS 活性基底仍然是一个主要挑战。在这里，我们报道了具有可调粒径和颗粒间间隙的金纳米粒子阵列的制备，并获得了高达 10(7)的 4-巯基吡啶探针分子的 SERS 信号增强因子。实验数据点表明，增强因子随直径与颗粒间间隙比的增加而增加，这可以用平均电磁场增强模型来解释。此外，我们证明了这种类型的基底具有高均匀性、高重现性和优异的长期稳定性。由于这种 SERS 基底的制造工艺简单且廉价，因此它可能在基于 SERS 的传感器中有广泛的应用。
