细胞周期调控因子在代谢控制中的作用。
Cell cycle regulators in the control of metabolism.
机构信息
INSERM U896 and IRCM, Institut de Recherche en Cancérologie de Montpellier and University Montpellier 1, Montpellier, France.
出版信息
Cell Cycle. 2009 Dec 15;8(24):4029-31. doi: 10.4161/cc.8.24.10110. Epub 2009 Dec 17.
Abstract
We recently showed that the CDK4-pRB-E2F1 cell cycle regulators directly regulate the expression of Kir6.2, which is a key component of the K(ATP) channel involved in the regulation of glucose-induced insulin secretion. There is enough evidence to indicate that the CDK4-pRB-E2F1 regulatory pathway is involved in general glucose homeostasis, and metabolism. In this article we discuss which are the metabolic implications of these findings.
摘要
我们最近表明，细胞周期调节因子 CDK4-pRB-E2F1 直接调节 Kir6.2 的表达，Kir6.2 是参与葡萄糖诱导胰岛素分泌调节的 K(ATP) 通道的关键组成部分。有足够的证据表明，CDK4-pRB-E2F1 调节途径参与了一般的葡萄糖稳态和代谢。在本文中，我们讨论了这些发现的代谢意义。
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本文引用的文献
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