INSERM U896 and IRCM, Institut de Recherche en Cancérologie de Montpellier and University Montpellier 1, Montpellier, France.
Cell Cycle. 2009 Dec 15;8(24):4029-31. doi: 10.4161/cc.8.24.10110. Epub 2009 Dec 17.
We recently showed that the CDK4-pRB-E2F1 cell cycle regulators directly regulate the expression of Kir6.2, which is a key component of the K(ATP) channel involved in the regulation of glucose-induced insulin secretion. There is enough evidence to indicate that the CDK4-pRB-E2F1 regulatory pathway is involved in general glucose homeostasis, and metabolism. In this article we discuss which are the metabolic implications of these findings.
我们最近表明，细胞周期调节因子 CDK4-pRB-E2F1 直接调节 Kir6.2 的表达，Kir6.2 是参与葡萄糖诱导胰岛素分泌调节的 K(ATP) 通道的关键组成部分。有足够的证据表明，CDK4-pRB-E2F1 调节途径参与了一般的葡萄糖稳态和代谢。在本文中，我们讨论了这些发现的代谢意义。
