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Bone: serotonin, leptin and the central control of bone remodeling.

作者信息

Rosen Clifford J

出版信息

Nat Rev Rheumatol. 2009 Dec;5(12):657-8. doi: 10.1038/nrrheum.2009.231.

DOI:10.1038/nrrheum.2009.231
PMID:19946292
Abstract
摘要

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1
Bone: serotonin, leptin and the central control of bone remodeling.骨骼:血清素、瘦素与骨重塑的中枢控制
Nat Rev Rheumatol. 2009 Dec;5(12):657-8. doi: 10.1038/nrrheum.2009.231.
2
Central control of bone remodeling.骨重塑的中枢控制
Biochem Biophys Res Commun. 2005 Mar 18;328(3):697-9. doi: 10.1016/j.bbrc.2004.11.071.
3
The impact of peripheral serotonin on leptin-brain serotonin axis, bone metabolism and strength in growing rats with experimental chronic kidney disease.外周血清素对实验性慢性肾脏病生长大鼠瘦素-脑血清素轴、骨代谢和力量的影响。
Bone. 2017 Dec;105:1-10. doi: 10.1016/j.bone.2017.08.004. Epub 2017 Aug 7.
4
Leptin's RIGHT turn to the brain stem.瘦素向脑干的右转。
Cell Metab. 2009 Oct;10(4):243-4. doi: 10.1016/j.cmet.2009.09.001.
5
[Serotonin, two faces of a unique molecule in the regulation of bone mass].[血清素,一种独特分子在骨量调节中的两面性]
Med Sci (Paris). 2010 Aug-Sep;26(8-9):713-8. doi: 10.1051/medsci/2010268-9713.
6
Leptin-dependent co-regulation of bone and energy metabolism.瘦素对骨骼与能量代谢的协同调节作用。
Aging (Albany NY). 2009 Nov 5;1(11):954-6. doi: 10.18632/aging.100100.
7
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.一种血清素依赖机制解释了瘦素对骨量、食欲和能量消耗的调节作用。
Cell. 2009 Sep 4;138(5):976-89. doi: 10.1016/j.cell.2009.06.051.
8
Neural regulation of bone remodeling: Identifying novel neural molecules and pathways between brain and bone.神经调控骨重塑:在大脑和骨骼之间鉴定新的神经分子和途径。
J Cell Physiol. 2019 May;234(5):5466-5477. doi: 10.1002/jcp.26502. Epub 2018 Dec 7.
9
Central control of bone formation.骨形成的中枢控制
J Bone Miner Metab. 2001;19(3):195-8. doi: 10.1007/s007740170042.
10
Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors.缺乏功能性5-羟色胺2C受体的ob/ob小鼠中葡萄糖稳态的协同损伤。
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Endocrine. 2013 Dec;44(3):790-802. doi: 10.1007/s12020-013-9962-6. Epub 2013 Apr 26.
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The complex interplay of depression and falls in older adults: a clinical review.老年人抑郁与跌倒之间的复杂相互作用:一项临床综述。
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本文引用的文献

1
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.一种血清素依赖机制解释了瘦素对骨量、食欲和能量消耗的调节作用。
Cell. 2009 Sep 4;138(5):976-89. doi: 10.1016/j.cell.2009.06.051.
2
Glucocorticoid-induced osteoporosis.糖皮质激素性骨质疏松症
Osteoporos Int. 2009 May;20 Suppl 3:S239-40. doi: 10.1007/s00198-008-0696-x.
3
Serotonin rising--the bone, brain, bowel connection.血清素上升——骨骼、大脑、肠道之间的联系。
基于结构的药效团与3D-QSAR联合研究苯丙氨酸系列化合物作为色氨酸羟化酶1抑制剂的作用
Int J Mol Sci. 2012;13(5):5348-5363. doi: 10.3390/ijms13055348. Epub 2012 May 2.
4
An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects.瘦素依赖性年龄相关作用揭示了生长激素释放肽的骨保护作用。
Endocrinology. 2012 Aug;153(8):3593-602. doi: 10.1210/en.2012-1277. Epub 2012 Jun 14.
5
Lean mass predicts hip geometry in men and women with non-insulin-requiring type 2 diabetes mellitus.非胰岛素依赖型 2 型糖尿病男性和女性的瘦体重可预测髋部几何结构。
J Clin Densitom. 2011 Jul-Sep;14(3):332-9. doi: 10.1016/j.jocd.2011.04.007. Epub 2011 Jun 11.
N Engl J Med. 2009 Mar 5;360(10):957-9. doi: 10.1056/NEJMp0810058.
4
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.Lrp5通过抑制十二指肠中血清素的合成来控制骨形成。
Cell. 2008 Nov 28;135(5):825-37. doi: 10.1016/j.cell.2008.09.059.
5
Medication-induced osteoporosis.药物性骨质疏松症
Curr Osteoporos Rep. 2007 Dec;5(4):139-45. doi: 10.1007/s11914-007-0008-y.
6
Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice.骨钙素可差异性调节β细胞和脂肪细胞的基因表达,并影响野生型小鼠代谢疾病的发展。
Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5266-70. doi: 10.1073/pnas.0711119105. Epub 2008 Mar 24.
7
Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone accrual during growth.血清素(5-羟色胺)转运蛋白的抑制会减少生长过程中的骨质积累。
Endocrinology. 2005 Feb;146(2):685-93. doi: 10.1210/en.2004-1259. Epub 2004 Nov 11.
8
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass.瘦素通过下丘脑传导途径抑制骨形成:对骨量的中枢控制。
Cell. 2000 Jan 21;100(2):197-207. doi: 10.1016/s0092-8674(00)81558-5.
9
Associations between low levels of serum estradiol, bone density, and fractures among elderly women: the study of osteoporotic fractures.老年女性血清雌二醇水平、骨密度与骨折之间的关联:骨质疏松性骨折研究
J Clin Endocrinol Metab. 1998 Jul;83(7):2239-43. doi: 10.1210/jcem.83.7.4708.
10
Fuller Albright. His concept of postmenopausal osteoporosis and what came of it.富勒·奥尔布赖特。他关于绝经后骨质疏松症的概念以及由此产生的影响。
Clin Orthop Relat Res. 1991 Aug(269):128-41.