Käyhty H, Eskola J, Peltola H, Rönnberg P R, Kela E, Karanko V, Saarinen L
Department of Bacteriology, National Public Health Institute, Helsinki, Finland.
Am J Dis Child. 1991 Feb;145(2):223-7. doi: 10.1001/archpedi.1991.02160020117030.
Serum antibody responses to four Haemophilus influenzae type b capsular polysaccharide-protein conjugate vaccines (PRP-D, HbOC, C7p, and PRP-T) were studied and compared in 175 infants, 85 adults and 140 2-year-old children. Antibodies to the H influenzae type b polysaccharide vaccines were determined with a Farr-type radioimmunoassay. The infants received two doses of vaccine at the ages of 4 and 6 months. After the first dose of vaccine, the geometric mean antibody concentration measured at the age of 6 months was 0.09 to 0.10 mg/L, only marginally higher than that measured before immunization in all infants who had received PRP-D, HbOC, or C7p but increased to 0.82 mg/L in those who had received PRP-T. One month after the second dose, the geometric mean antibody concentration was increased in all vaccine groups. No significant differences were noted between recipients of HbOC, C7p, or PRP-T (geometric mean antibody concentrations, 4.32, 3.10, and 6.10 mg/L, respectively), whereas the PRP-D recipients had a significantly lower geometric mean antibody concentration (0.63 mg/L). In contrast, PRP-D, HbOC, C7p, and PRP-T were all highly immunogenic in adults, with no differences noted among them. The 2-year-old children also responded to one dose of these vaccines with a high antibody concentration.
在175名婴儿、85名成年人和140名2岁儿童中研究并比较了对四种b型流感嗜血杆菌结合疫苗（PRP-D、HbOC、C7p和PRP-T）的血清抗体反应。采用Farr型放射免疫测定法测定b型流感嗜血杆菌多糖疫苗的抗体。婴儿在4个月和6个月龄时接种两剂疫苗。首剂疫苗接种后，6个月龄时测得的几何平均抗体浓度为0.09至0.10mg/L，在所有接种PRP-D、HbOC或C7p的婴儿中仅略高于免疫前水平，但在接种PRP-T的婴儿中升至0.82mg/L。第二剂接种后1个月，所有疫苗组的几何平均抗体浓度均升高。HbOC、C7p或PRP-T接种者之间未观察到显著差异（几何平均抗体浓度分别为4.32、3.10和6.10mg/L），而PRP-D接种者的几何平均抗体浓度显著较低（0.63mg/L）。相比之下，PRP-D、HbOC、C7p和PRP-T在成年人中均具有高度免疫原性，彼此之间未观察到差异。2岁儿童对这些疫苗的一剂接种也有高抗体浓度反应。
