Scheen A J, Lefebvre P J
Université de Liège, Belgique.
Rev Med Liege. 2009 Sep;64(9):440-5.
Insulin glargine is widely used as basal insulin in the treatment of type 1 and type 2 diabetes mellitus. However, this insulin analogue has been recently suspected to be associated with an increased risk of cancer, especially breast cancer, in patients with type 2 diabetes. The present article aims at briefly presenting the state of the art based upon currently available data. We will first summarize the observations reported in recent publications, then we will present a critical analysis of these in fact non-conclusive findings, and finally we will conclude with some practical recommendations.
甘精胰岛素作为基础胰岛素被广泛用于治疗1型和2型糖尿病。然而,这种胰岛素类似物最近被怀疑与2型糖尿病患者患癌风险增加有关,尤其是乳腺癌。本文旨在根据现有数据简要介绍最新情况。我们将首先总结近期出版物中报道的观察结果,然后对这些实际上尚无定论的发现进行批判性分析,最后给出一些实用建议作为结论。