Sotnikov V M, Pan'shin G A, Datsenko P V, Ivashin A V, Smol'tsova N N
Vopr Onkol. 2009;55(4):443-6.
Immediate and end results of chemoradiotherapy of 225 patients (average age--43 years) with primary aggressive non-Hodgkin's lymphomas stage III-IV were evaluated. Stage 1 of treatment included 4-8 cycles of chemotherapy (ACOP and other standard protocols); stage 2--irradiation of residual foci with 20-50 Gy, or 20-36 Gy for originally extensive and extralymphatic foci when in full remission. The latter's rate rose from 24 to 65% (p < or = 0.05) following adjuvant radiotherapy although that of failures remained unchanged. The disease is specific, so relapse-free survival in cases of generalized primary aggressive lymphoma in full remission remained unchanged too whatever the stage at which full remission emerged.
对225例（平均年龄43岁）原发性III-IV期侵袭性非霍奇金淋巴瘤患者进行放化疗的近期和远期疗效进行了评估。治疗的第1阶段包括4-8个周期的化疗（ACOP及其他标准方案）；第2阶段——对残留病灶进行20-50Gy的照射，对于最初广泛且有结外病灶的患者，若完全缓解则给予20-36Gy的照射。辅助放疗后，完全缓解率从24%升至65%（p≤0.05），但失败率保持不变。该疾病具有特异性，因此无论完全缓解出现在哪个阶段，全身原发性侵袭性淋巴瘤完全缓解病例的无复发生存率也保持不变。
