Titova V A, Kharchenko N V, Dobrovol'skaia N Iu, Kreĭnina Iu M
Vopr Onkol. 2009;55(4):471-3.
We used combinations of taxan-based neoadjuvant and adjuvant full-dose chemotherapy and aggressive combined radiotherapy including clinical target volume extension, increased total dosage, hyperthermia, cryo- and local chemotherapy as radiosensitizers, for treatment of invasive and locally-advanced breast cancer or endometrial carcinoma with poor prognosis. 3D-ultrasound/CT/MRI--based designing of radiotherapy and monitoring of dynamic definition of target volume and "high risk volume" in organs at risk in cases of tumor progression was an indispensable measure. As a result, no local recurrence was reported in 73% for 36 months.
我们采用基于紫杉烷的新辅助和辅助全剂量化疗联合积极的综合放疗，包括临床靶体积扩展、增加总剂量、热疗、冷冻和局部化疗作为放射增敏剂，用于治疗侵袭性和局部晚期乳腺癌或预后不良的子宫内膜癌。基于三维超声/CT/MRI进行放疗设计以及在肿瘤进展情况下对靶体积和危及器官中的“高危体积”进行动态定义监测是一项必不可少的措施。结果，36个月时73%的患者未报告局部复发。
