Kobalava Zh D, Kotovskaia Iu V, Tiul'kina E E
Ter Arkh. 2009;81(10):64-70.
The review summarizes the current views on the pathogenesis of dementia and the significance of blood pressure levels for its development. The present status of the prevention of cognitive disorders and dementia is detailed in the use of antihypertensive therapy: there are the data of prospective cohort studies of the impact of antihypertensive therapy on the risk of dementia, the results of placebo-controlled studies in the groups of elderly and senile patients with a history of cerebrovascular complications, and the data of meta-analyses of studies. As for cognitive function, the effects of different classes of the currently available antihypertensive agents, such as diuretics, calcium antagonists, angiotensin-converting enzyme inhibitors, and angiotensin II type 1 receptor antagonists, are analyzed.
本综述总结了目前关于痴呆症发病机制的观点以及血压水平对其发展的意义。在使用抗高血压治疗方面详细阐述了预防认知障碍和痴呆症的现状：有前瞻性队列研究关于抗高血压治疗对痴呆症风险影响的数据、在有脑血管并发症病史的老年和高龄患者组中进行的安慰剂对照研究结果以及研究的荟萃分析数据。至于认知功能，分析了目前可用的不同类别的抗高血压药物，如利尿剂、钙拮抗剂、血管紧张素转换酶抑制剂和血管紧张素II 1型受体拮抗剂的作用。
