Gamidov S I, Shcherbakov D V, Tkhagapsoeva R A, Koroteev R V
Ter Arkh. 2009;81(10):70-3.
To study the influence of long-term of vardenafil use on endothelial and erectile functions in patients with arteriogenic erectile dysfunction (ED).
The study included 74 arteriogenic ED patients (mean age 57.4 +/- 4.7 years). In addition to a comprehensive andrological examination, all the patients underwent the estimation of the endothelial function of cavernous arteries, the indicator of which is the percentage increase in the diameter of cavernous arteries. The patients were divided into 3 groups: 1) 24 patients receiving vardenafil on demand in a dose of 10 mg; 2) 26 patients taking the drug on demand in a dose of 20 mg; and 3) 24 patients regularly using the agent in a dose of 10 mg every other day. Endothelial and erective functions were re-estimated 1, 3, and 6 months after the initiation of vardenafil therapy and a month following its discontinuation.
Erectile function improvement was noted just a month after the initiation of vardenafil therapy and achieved the maximum values by month 6. The highest erectile function parameters were observed in Group 3. There was a significant endothelial function improvement only in Group 3; the peak effect was achieved by month 6 of treatment.
The long-term use of vardenafil contributes to the improvement of both erectile and endothelial functions in patients with arteriogenic ED.
研究长期使用伐地那非对动脉性勃起功能障碍（ED）患者内皮功能和勃起功能的影响。
该研究纳入了74例动脉性ED患者（平均年龄57.4±4.7岁）。除了全面的男科检查外，所有患者均接受了海绵体动脉内皮功能评估，评估指标为海绵体动脉直径增加的百分比。患者被分为3组：1）24例按需服用10mg伐地那非的患者；2）26例按需服用20mg药物的患者；3）24例每隔一天规律服用10mg药物的患者。在伐地那非治疗开始后1、3和6个月以及停药后1个月重新评估内皮功能和勃起功能。
伐地那非治疗开始仅1个月后就注意到勃起功能改善，并在第6个月达到最大值。第3组观察到最高的勃起功能参数。仅第3组内皮功能有显著改善；治疗第6个月达到峰值效应。
长期使用伐地那非有助于改善动脉性ED患者的勃起功能和内皮功能。
