Zhang Liangke, Yuan Pei, Tian Rui, Ling Xu, Yu Ruijie
Chongqing Key Laboratory of Biochemistry & Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Oct;26(5):1030-3.
This study was aimed to reveal how the swelling properties and release behavior of a model drug from pectin gel beads were influenced by its crosslinking with different metal ions. Coomassie Brilliant Blue G-250 was chosen as the model drug. Pectinate beads were prepared by the dropping method and crosslinked with Ca2+, Fe3+, Zn2+, Ba2+, respectively. The release behavior and swelling properties were investigated. The results showed that there were significant differences between the pectinate beads that were crosslinked with different ions. Pectinate gel beads, as a potential cell microencapsulation and drug vehicle, could be acquired for different release profile by crosslinking with different ions.
本研究旨在揭示模型药物从果胶凝胶珠中的溶胀特性和释放行为如何受到其与不同金属离子交联的影响。选择考马斯亮蓝G-250作为模型药物。通过滴加法制备果胶珠，并分别与Ca2+、Fe3+、Zn2+、Ba2+交联。研究了其释放行为和溶胀特性。结果表明，与不同离子交联的果胶珠之间存在显著差异。果胶凝胶珠作为一种潜在的细胞微囊化和药物载体，通过与不同离子交联可获得不同的释放曲线。
