[脑缺血后钙蛋白酶与细胞凋亡的研究进展]

[Study advancement of calpain and apoptosis following cerebral ischemia].

作者信息

Liu Jian, Xu Junfeng, Wang Guangjun, Yang Mingxing, Guo Lin

机构信息

Institue of Acupuncture and Moxibustion, Frist Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Oct;26(5):1150-3.

PMID:19947509

Abstract

Calpains, calcium-activated cysteine proteases with a neutral pH optimum, lead to degration of cystoskeletion and structural protein, and delayed neuronal death. The activation of calpains contribute to apoptosis. Calpain inhibitors provide a novel and potential treatment for cerebral ischemia due to improvement of cerebral infarct and ischemia.

摘要

钙蛋白酶是一种最适pH为中性的钙激活半胱氨酸蛋白酶，可导致细胞骨架和结构蛋白降解，并延缓神经元死亡。钙蛋白酶的激活会促使细胞凋亡。由于可改善脑梗死和缺血情况，钙蛋白酶抑制剂为脑缺血提供了一种新的潜在治疗方法。