Shanghai University, Mathematics Department, Shanghai, Pepole's Republic of China.
IET Syst Biol. 2009 Nov;3(6):496-504. doi: 10.1049/iet-syb.2009.0001.
In the past, most research on gene regulation has focused on transcriptional regulation and post-translational regulation. Recently, the post-transcriptional regulation by small non-coding RNAs has drawn much attention. This mode of regulation was found in both prokaryotes and eukaryotes. In this study, the authors integrate transcriptional and post-transcriptional regulation into four different kinds of microRNA-mediated motifs and investigate the mechanism of microRNAs regulation from the viewpoints of dynamics. Theoretical analysis and numerical simulations show that all the four motifs exhibit strong robustness to external and stochastic perturbations.
过去，大多数基因调控研究集中在转录调控和翻译后调控上。最近，小非编码 RNA 的转录后调控引起了广泛关注。这种调控模式在原核生物和真核生物中都存在。在这项研究中，作者将转录和转录后调控整合到四种不同的 microRNA 介导的基序中，并从动力学的角度研究 microRNA 调控的机制。理论分析和数值模拟表明，所有四种基序对外部和随机扰动都具有很强的鲁棒性。
