Queen Elizabeth Hospital, Birmingham, UK.
Expert Opin Drug Saf. 2010 Jan;9(1):139-47. doi: 10.1517/14740330903418430.
Amphotericin B lipid complex is a widely used lipid-based formulation of amphotericin B, which has a broad spectrum of activity against a variety of fungal pathogens. It has also been shown to be significantly less nephrotoxic than conventional amphotericin B. However, infusional drug reactions, similar to those seen when using conventional amphotericin B, have been reported in a significant number of patients, so it is important that these are prevented or managed effectively, particularly in light of the changing epidemiology of systemic fungal infections.
This article reviews effective strategies that can be used to reduce the risk of drug delivery reactions associated with amphotericin B lipid complex. Preserving renal function and managing spikes in serum creatinine levels are also discussed.
The aim of this paper is to provide healthcare professionals with clear guidance on the management of adverse events associated with amphotericin B lipid complex. Recommendations are based upon the published evidence and clinical experience from a number of different centres.
Amphotericin B lipid complex represents a valuable therapeutic option in the treatment of fungal infections but improved strategies for the management of infusion-related adverse events are required.
两性霉素 B 脂质复合物是一种广泛使用的两性霉素 B 脂质制剂，对多种真菌病原体具有广泛的活性。它也被证明比传统两性霉素 B 的肾毒性小得多。然而，在大量患者中报告了类似于使用传统两性霉素 B 时出现的输注药物反应，因此，重要的是要预防或有效管理这些反应，特别是考虑到系统性真菌感染的流行病学变化。
本文综述了可用于降低与两性霉素 B 脂质复合物相关的药物输送反应风险的有效策略。还讨论了保留肾功能和管理血清肌酐水平升高的问题。
本文的目的是为医疗保健专业人员提供有关两性霉素 B 脂质复合物相关不良反应管理的明确指导。建议基于一些不同中心的发表证据和临床经验。
两性霉素 B 脂质复合物是治疗真菌感染的一种有价值的治疗选择，但需要改进管理输液相关不良反应的策略。
