HMGN蛋白对染色质结构和功能的调控。
Regulation of chromatin structure and function by HMGN proteins.
作者信息
Postnikov Yuri, Bustin Michael
机构信息
Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA.
出版信息
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):62-8. doi: 10.1016/j.bbagrm.2009.11.016. Epub 2009 Nov 27.
Abstract
High mobility group nucleosome-binding (HMGN) proteins are architectural non-histone chromosomal proteins that bind to nucleosomes and modulate the structure and function of chromatin. The interaction of HMGN proteins with nucleosomes is dynamic and the proteins compete with the linker histone H1 chromatin-binding sites. HMGNs reduce the H1-mediated compaction of the chromatin fiber and facilitate the targeting of regulatory factors to chromatin. They modulate the cellular epigenetic profile, affect gene expression and impact the biological processes such as development and the cellular response to environmental and hormonal signals. Here we review the role of HMGN in chromatin structure, the link between HMGN proteins and histone modifications, and discuss the consequence of this link on nuclear processes and cellular phenotype.
摘要
高迁移率族核小体结合（HMGN）蛋白是一类非组蛋白染色体结构蛋白，可与核小体结合并调节染色质的结构和功能。HMGN蛋白与核小体的相互作用是动态的，这些蛋白与连接组蛋白H1的染色质结合位点相互竞争。HMGN蛋白可减少H1介导的染色质纤维压缩，并促进调节因子靶向染色质。它们调节细胞表观遗传特征，影响基因表达，并影响诸如发育以及细胞对环境和激素信号的反应等生物学过程。在此，我们综述了HMGN在染色质结构中的作用、HMGN蛋白与组蛋白修饰之间的联系，并讨论了这种联系对核过程和细胞表型的影响。
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