HMGN蛋白的转录调控
Transcriptional regulation by HMGN proteins.
作者信息
Zhu Nan, Hansen Ulla
机构信息
Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA.
出版信息
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):74-9. doi: 10.1016/j.bbagrm.2009.11.006.
Abstract
High mobility group nucleosomal proteins (HMGNs) are small non-histone proteins associated with chromatin. HMGNs have the unique ability to bind to nucleosomes with higher affinity than to naked DNA [1]. They have been studied extensively for their ability to modulate transcription. Although initially viewed as general transcriptional activators on chromatin templates, it is now appreciated that they are instead highly specific modulators of gene expression. We review the mechanisms for targeting HMGNs to specific genes and for how they subsequently regulate transcription.
摘要
高迁移率族核小体蛋白（HMGNs）是与染色质相关的小型非组蛋白。HMGNs具有独特的能力，与核小体结合的亲和力高于与裸露DNA的结合亲和力[1]。它们因其调节转录的能力而受到广泛研究。尽管最初被视为染色质模板上的一般转录激活因子，但现在人们认识到它们实际上是基因表达的高度特异性调节因子。我们综述了HMGNs靶向特定基因的机制以及它们随后如何调节转录。
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本文引用的文献
1
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Mol Cell Biol. 2009 Oct;29(19):5264-76. doi: 10.1128/MCB.00526-09. Epub 2009 Aug 3.
2
HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility.
Mol Cell. 2009 Jun 12;34(5):620-6. doi: 10.1016/j.molcel.2009.04.014.
3
A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions.
PLoS One. 2009;4(4):e5050. doi: 10.1371/journal.pone.0005050. Epub 2009 Apr 1.
4
Histone H1 and its isoforms: contribution to chromatin structure and function.
Gene. 2009 Feb 15;431(1-2):1-12. doi: 10.1016/j.gene.2008.11.003. Epub 2008 Nov 14.
5
Cell cycle-dependent binding of HMGN proteins to chromatin.
Mol Biol Cell. 2008 May;19(5):1816-24. doi: 10.1091/mbc.e07-10-1018. Epub 2008 Feb 20.
6
Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling.
Nucleic Acids Res. 2008 Feb;36(2):462-76. doi: 10.1093/nar/gkm1047. Epub 2007 Nov 27.
7
HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors.
Mol Cell Biol. 2007 Dec;27(24):8859-73. doi: 10.1128/MCB.01724-07. Epub 2007 Oct 15.
8
HMG chromosomal proteins in development and disease.
Trends Cell Biol. 2007 Feb;17(2):72-9. doi: 10.1016/j.tcb.2006.12.001. Epub 2006 Dec 13.
9
Chromosomal protein HMGN1 modulates the phosphorylation of serine 1 in histone H2A.
Biochemistry. 2006 Dec 19;45(50):15092-9. doi: 10.1021/bi0613271.
10
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Cancer Res. 2006 May 1;66(9):4610-6. doi: 10.1158/0008-5472.CAN-05-4251.
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