HMGN蛋白的转录调控
Transcriptional regulation by HMGN proteins.
作者信息
Zhu Nan, Hansen Ulla
机构信息
Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA.
出版信息
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):74-9. doi: 10.1016/j.bbagrm.2009.11.006.
Abstract
High mobility group nucleosomal proteins (HMGNs) are small non-histone proteins associated with chromatin. HMGNs have the unique ability to bind to nucleosomes with higher affinity than to naked DNA [1]. They have been studied extensively for their ability to modulate transcription. Although initially viewed as general transcriptional activators on chromatin templates, it is now appreciated that they are instead highly specific modulators of gene expression. We review the mechanisms for targeting HMGNs to specific genes and for how they subsequently regulate transcription.
摘要
高迁移率族核小体蛋白（HMGNs）是与染色质相关的小型非组蛋白。HMGNs具有独特的能力，与核小体结合的亲和力高于与裸露DNA的结合亲和力[1]。它们因其调节转录的能力而受到广泛研究。尽管最初被视为染色质模板上的一般转录激活因子，但现在人们认识到它们实际上是基因表达的高度特异性调节因子。我们综述了HMGNs靶向特定基因的机制以及它们随后如何调节转录。
相似文献
1
Transcriptional regulation by HMGN proteins.HMGN蛋白的转录调控
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):74-9. doi: 10.1016/j.bbagrm.2009.11.006.
2
Regulation of chromatin structure and function by HMGN proteins.HMGN蛋白对染色质结构和功能的调控。
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):62-8. doi: 10.1016/j.bbagrm.2009.11.016. Epub 2009 Nov 27.
3
HMGN5/NSBP1: a new member of the HMGN protein family that affects chromatin structure and function.HMGN5/NSBP1：一种影响染色质结构与功能的HMGN蛋白家族新成员。
Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):86-92. doi: 10.1016/j.bbagrm.2009.09.012.
4
The HMGN family of chromatin-binding proteins: dynamic modulators of epigenetic processes.染色质结合蛋白HMGN家族：表观遗传过程的动态调节因子。
Biochim Biophys Acta. 2012 Jul;1819(7):652-6. doi: 10.1016/j.bbagrm.2012.01.013. Epub 2012 Feb 2.
5
H3K27ac nucleosomes facilitate HMGN localization at regulatory sites to modulate chromatin binding of transcription factors.H3K27ac 核小体有助于 HMGN 定位于调控位点，从而调节转录因子与染色质的结合。
Commun Biol. 2022 Feb 23;5(1):159. doi: 10.1038/s42003-022-03099-0.
6
High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.高迁移率族蛋白 N 以组织和变体特异性的方式调节细胞转录谱的保真度。
J Biol Chem. 2013 Jun 7;288(23):16690-16703. doi: 10.1074/jbc.M113.463315. Epub 2013 Apr 24.
7
HMGN proteins modulate chromatin regulatory sites and gene expression during activation of naïve B cells.HMGN蛋白在幼稚B细胞激活过程中调节染色质调控位点和基因表达。
Nucleic Acids Res. 2016 Sep 6;44(15):7144-58. doi: 10.1093/nar/gkw323. Epub 2016 Apr 25.
8
The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription.NSBP1/HMGN5与常染色质中的核小体相互作用，可抵消连接组蛋白介导的染色质压缩并调节转录。
Mol Cell. 2009 Sep 11;35(5):642-56. doi: 10.1016/j.molcel.2009.07.002.
9
HMGN dynamics and chromatin function.HMGN动态变化与染色质功能。
Biochem Cell Biol. 2003 Jun;81(3):113-22. doi: 10.1139/o03-040.
10
Epigenetic regulation of REX1 expression and chromatin binding specificity by HMGNs.组蛋白 HMGN 对 REX1 表达和染色质结合特异性的表观遗传调控。
Nucleic Acids Res. 2019 May 21;47(9):4449-4461. doi: 10.1093/nar/gkz161.
引用本文的文献
1
Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3.发育必需蛋白 Hmx3a/HMX3 的结合伴侣和功能结构域分析。
Sci Rep. 2023 Jan 20;13(1):1151. doi: 10.1038/s41598-023-27878-9.
2
High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis.高迁移率族核小体结合结构域2通过在皮质发生过程中维持整体染色质可及性来预防小头畸形。
J Biol Chem. 2020 Jan 10;295(2):468-480. doi: 10.1074/jbc.RA119.010616. Epub 2019 Nov 7.
3
A simple and versatile system for the ATP-dependent assembly of chromatin.一种用于依赖ATP的染色质组装的简单通用系统。
J Biol Chem. 2017 Nov 24;292(47):19478-19490. doi: 10.1074/jbc.M117.815365. Epub 2017 Oct 5.
4
Knockdown of HMGN5 suppresses the viability and invasion of human urothelial bladder cancer 5637 cells in vitro and in vivo.HMGN5基因敲低抑制人膀胱尿路上皮癌5637细胞在体外和体内的活力及侵袭能力。
Med Oncol. 2015 Apr;32(4):136. doi: 10.1007/s12032-015-0594-y. Epub 2015 Mar 22.
5
Evolution of high mobility group nucleosome-binding proteins and its implications for vertebrate chromatin specialization.高迁移率族核小体结合蛋白的进化及其对脊椎动物染色质特化的影响。
Mol Biol Evol. 2015 Jan;32(1):121-31. doi: 10.1093/molbev/msu280. Epub 2014 Oct 3.
6
Domains of genome-wide gene expression dysregulation in Down's syndrome.唐氏综合征中全基因组基因表达失调的域。
Nature. 2014 Apr 17;508(7496):345-50. doi: 10.1038/nature13200.
7
The nucleosome binding protein HMGN1 interacts with PCNA and facilitates its binding to chromatin.核小体结合蛋白 HMGN1 与 PCNA 相互作用，并促进其与染色质结合。
Mol Cell Biol. 2012 May;32(10):1844-54. doi: 10.1128/MCB.06429-11. Epub 2012 Mar 5.
8
The HMGN family of chromatin-binding proteins: dynamic modulators of epigenetic processes.染色质结合蛋白HMGN家族：表观遗传过程的动态调节因子。
Biochim Biophys Acta. 2012 Jul;1819(7):652-6. doi: 10.1016/j.bbagrm.2012.01.013. Epub 2012 Feb 2.
9
Distinct properties of human HMGN5 reveal a rapidly evolving but functionally conserved nucleosome binding protein.人类 HMGN5 的独特性质揭示了一种快速进化但功能保守的核小体结合蛋白。
Mol Cell Biol. 2011 Jul;31(13):2742-55. doi: 10.1128/MCB.05216-11. Epub 2011 Apr 25.
本文引用的文献
1
The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion.核小体结合蛋白HMGN3调节胰腺β细胞的转录谱并影响胰岛素分泌。
Mol Cell Biol. 2009 Oct;29(19):5264-76. doi: 10.1128/MCB.00526-09. Epub 2009 Aug 3.
2
HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility.HMGN蛋白的作用与ATP依赖的染色质重塑因子相反，以限制核小体的移动性。
Mol Cell. 2009 Jun 12;34(5):620-6. doi: 10.1016/j.molcel.2009.04.014.
3
A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions.HSF1和NFIX的DNA序列定向相互转录调控涉及新型热敏感蛋白相互作用。
PLoS One. 2009;4(4):e5050. doi: 10.1371/journal.pone.0005050. Epub 2009 Apr 1.
4
Histone H1 and its isoforms: contribution to chromatin structure and function.组蛋白H1及其亚型：对染色质结构和功能的贡献。
Gene. 2009 Feb 15;431(1-2):1-12. doi: 10.1016/j.gene.2008.11.003. Epub 2008 Nov 14.
5
Cell cycle-dependent binding of HMGN proteins to chromatin.HMGN蛋白与染色质的细胞周期依赖性结合。
Mol Biol Cell. 2008 May;19(5):1816-24. doi: 10.1091/mbc.e07-10-1018. Epub 2008 Feb 20.
6
Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling.与染色质相关的HMG-17是由Wnt/β-连环蛋白信号传导调节的同源域转录因子活性的主要调节因子。
Nucleic Acids Res. 2008 Feb;36(2):462-76. doi: 10.1093/nar/gkm1047. Epub 2007 Nov 27.
7
HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors.HMGN1通过与特定的DNA结合转录因子相互作用来调节雌激素介导的转录激活。
Mol Cell Biol. 2007 Dec;27(24):8859-73. doi: 10.1128/MCB.01724-07. Epub 2007 Oct 15.
8
HMG chromosomal proteins in development and disease.发育与疾病中的HMG染色体蛋白。
Trends Cell Biol. 2007 Feb;17(2):72-9. doi: 10.1016/j.tcb.2006.12.001. Epub 2006 Dec 13.
9
Chromosomal protein HMGN1 modulates the phosphorylation of serine 1 in histone H2A.染色体蛋白HMGN1调节组蛋白H2A中丝氨酸1的磷酸化。
Biochemistry. 2006 Dec 19;45(50):15092-9. doi: 10.1021/bi0613271.
10
Chromatin modification of the trefoil factor 1 gene in human breast cancer cells by the Ras/mitogen-activated protein kinase pathway.Ras/丝裂原活化蛋白激酶途径对人乳腺癌细胞中三叶因子1基因的染色质修饰
Cancer Res. 2006 May 1;66(9):4610-6. doi: 10.1158/0008-5472.CAN-05-4251.
Zotero 插件