Birmingham and Midland Eye Centre, City Hospital, Dudley Road, Birmingham, West Midlands, UK.
Arch Dis Child Fetal Neonatal Ed. 2010 May;95(3):F174-6. doi: 10.1136/adc.2009.160366. Epub 2009 Nov 29.
To assess the risk of severe retinopathy of prematurity (ROP) requiring treatment in different ethnic groups.
Retrospective observational study on ROP screening and treatment. It involved a cross-sectional review of all eligible infants over a seven-year period. Statistical tests used were the Kruskal-Wallis test and Mann-Whitney U test. Logistic regression was used to control for any differences in birth weight and gestational age.
City Hospital and Birmingham Women's Hospital, Birmingham, UK.
1690 preterm infants underwent ROP screening. Birth weight was lower in black (1142.5 g) and Asian infants (1180 g) when compared to white infants (1196.5 g). Gestational age was lower in black infants (28.5 weeks) compared to Asian and white infants (both 29 weeks). Compared to white infants, the odds of severe ROP requiring treatment was higher in Asian infants (odds ratio (OR): 2.52; 95% CI 1.41 to 4.50) and black infants (OR: 2.51; 95% CI 1.30 to 4.86). The additional risk from ethnicity was present even after adjusting for birth weight and gestational age (adjusted OR for Asian vs white infants: 2.45; 95% CI 1.334 to 4.497); (adjusted OR for black vs white infants: 2.0; 95% CI 1.004 to 4.014).
Ethnicity is a risk factor for severe ROP. Asian and black infants have a higher risk of developing threshold ROP compared to white infants.
评估不同种族群体中需要治疗的严重早产儿视网膜病变（ROP）的风险。
ROP 筛查和治疗的回顾性观察研究。它涉及对 7 年内所有符合条件的婴儿进行横断面回顾。使用的统计检验是 Kruskal-Wallis 检验和 Mann-Whitney U 检验。使用逻辑回归来控制出生体重和胎龄的任何差异。
英国伯明翰市医院和伯明翰妇女医院。
1690 名早产儿接受了 ROP 筛查。与白人婴儿（1196.5g）相比，黑人（1142.5g）和亚洲婴儿（1180g）的出生体重较低。黑人婴儿（28.5 周）的胎龄低于亚洲和白人婴儿（均为 29 周）。与白人婴儿相比，亚洲婴儿（优势比（OR）：2.52；95%置信区间（CI）1.41 至 4.50）和黑人婴儿（OR：2.51；95%CI 1.30 至 4.86）发生严重 ROP 需要治疗的几率更高。即使在调整了出生体重和胎龄后，种族带来的额外风险仍然存在（与白人婴儿相比，亚洲婴儿的调整后的 OR：2.45；95%CI 1.334 至 4.497）；（与白人婴儿相比，黑人婴儿的调整后的 OR：2.0；95%CI 1.004 至 4.014）。
种族是严重 ROP 的一个危险因素。与白人婴儿相比，亚洲和黑人婴儿发生阈值 ROP 的风险更高。
