肾脏与酸碱调节。

The kidney and acid-base regulation.

机构信息

School of Medicine, University of Connecticut, Farmington, Connecticut, 06030-1920, USA.

出版信息

Adv Physiol Educ. 2009 Dec;33(4):275-81. doi: 10.1152/advan.00054.2009.

DOI:10.1152/advan.00054.2009

PMID:19948674

Abstract

Since the topic of the role of the kidneys in the regulation of acid-base balance was last reviewed from a teaching perspective (Koeppen BM. Renal regulation of acid-base balance. Adv Physiol Educ 20: 132-141, 1998), our understanding of the specific membrane transporters involved in H(+), HCO(3)(-), and NH(4)(+) transport, and especially how these transporters are regulated in response to systemic acid-base disorders, has advanced considerably. In this review, these new aspects of renal function are presented, as are the broader and more general concepts related to the role of the kidneys in maintaining the acid-base balance. It is intended that this review will assist those who teach this aspect of human physiology to first-year health profession students.

摘要

自上次从教学角度回顾肾脏在酸碱平衡调节中的作用这一主题（Koeppen BM. Renal regulation of acid-base balance. Adv Physiol Educ 20: 132-141, 1998）以来，我们对涉及 H(+)、HCO(3)(-) 和 NH(4)(+) 转运的特定膜转运体的理解，尤其是这些转运体如何响应全身酸碱紊乱进行调节的理解，已经取得了很大进展。在这篇综述中，介绍了肾功能的这些新方面，以及与肾脏在维持酸碱平衡中的作用相关的更广泛和更一般的概念。本综述旨在帮助向一年级健康专业学生教授这方面人体生理学的人。