Department of Internal Medicine, CHA University, CHA Gumi Medical Center, Gumi, Korea.
Korean Circ J. 2009 Oct;39(10):423-7. doi: 10.4070/kcj.2009.39.10.423. Epub 2009 Oct 28.
The gender differences among Korean patients with coronary spasm have not been defined. We thus determined the gender differences among Korean patients with coronary spasm.
Patients with chest pain and/or syncope who were admitted to Kyungpook National University Hospital between January 2001 and August 2008 were included. Provocation of coronary vasospasm with intracoronary ergonovine maleate was performed when baseline coronary angiography showed no significant stenosis or there was a strong clinical suspicion of coronary spasm. The clinical characteristics were analyzed from 104 consecutive patients (56+/-9 years of age; 21 females) who were diagnosed with coronary spasm.
Female patients were younger (52+/-7 vs. 57+/-10 years, p=0.046) with lower rates of smoking and alcohol consumption histories than male patients (19% vs. 65%, p<0.001; and 43% vs. 89%, p<0.001, respectively). The other clinical characteristics were not significantly different, except for the triglyceride levels.
The majority of patients with coronary spasm were males who were smokers and alcohol consumers. The female patients had lower rates of smoking and alcohol consumption, and they were younger than the male patients. Further studies are needed to investigate the relevance of gender differences in the pathogenesis of coronary spasm.
韩国冠状动脉痉挛患者的性别差异尚未明确。因此，我们确定了韩国冠状动脉痉挛患者的性别差异。
本研究纳入了 2001 年 1 月至 2008 年 8 月期间因胸痛和/或晕厥而入住庆北国立大学医院的患者。当基线冠状动脉造影显示无明显狭窄或强烈怀疑冠状动脉痉挛时，通过冠状动脉内麦角新碱激发试验诱发冠状动脉痉挛。对 104 例连续确诊为冠状动脉痉挛的患者（56±9 岁；21 名女性）的临床特征进行了分析。
与男性患者相比，女性患者年龄更小（52±7 岁 vs. 57±10 岁，p=0.046），吸烟史和饮酒史的发生率更低（19% vs. 65%，p<0.001；43% vs. 89%，p<0.001）。其他临床特征除了甘油三酯水平外，均无显著差异。
冠状动脉痉挛患者以男性为主，这些男性患者多有吸烟和饮酒史。女性患者吸烟和饮酒的比例较低，且比男性患者年轻。需要进一步的研究来探讨冠状动脉痉挛发病机制中性别差异的相关性。
