Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Int J Hematol. 2010 Jan;91(1):107-11. doi: 10.1007/s12185-009-0453-8. Epub 2009 Dec 2.
Nasal natural killer (NK)/T cell lymphoma is a rare disease with a poor prognosis. We report the case of a 52-year-old woman with progressive advanced nasal NK/T cell lymphoma, with local invasiveness and bone marrow involvement, who was successfully treated with unrelated cord blood transplantation (UCBT). The patient was initially refractory to conventional chemotherapy. She was therefore treated with local irradiation, which induced a partial response. The patient then underwent UCBT using a conditioning regimen consisting of cyclophosphamide and total body irradiation. Acute graft-versus-host disease involving the skin was observed, but it was well controlled without systemic administration of corticosteroids. The patient remained in complete remission for 18 months after UCBT. Although the observation period has been relatively short and longer follow-up is needed, our observations suggest that incorporating focal irradiation to conditioning regimen for local control might be an effective treatment option for advanced nasal NK/T cell lymphoma in the setting of UCBT.
鼻腔自然杀伤（NK）/T 细胞淋巴瘤是一种预后不良的罕见疾病。我们报告了一例 52 岁女性患有进行性晚期鼻腔 NK/T 细胞淋巴瘤，具有局部侵袭性和骨髓受累，经无关脐带血移植（UCBT）成功治疗。患者最初对常规化疗无反应。因此，她接受了局部放疗，诱导部分缓解。然后，患者接受了包含环磷酰胺和全身照射的预处理方案的 UCBT。观察到急性移植物抗宿主病累及皮肤，但无需全身使用皮质类固醇即可得到良好控制。UCBT 后 18 个月，患者仍处于完全缓解状态。尽管观察期相对较短，需要更长时间的随访，但我们的观察结果表明，在 UCBT 中，将局部控制的预处理方案中加入局部照射可能是晚期鼻腔 NK/T 细胞淋巴瘤的有效治疗选择。
