Department of Cardiology, University of Mersin School of Medicine, Mersin, Turkey.
Swiss Med Wkly. 2009 Nov 14;139(45-46):672-5. doi: 10.57187/smw.2009.12759.
Prostate specific antigen (PSA) is the most important biochemical marker in the diagnosis and follow-up of patients with prostate cancer. In recent years, a relationship between PSA levels and cardiovascular conditions has been described. However, no study has investigated the PSA levels after coronary stenting.
To investigate the impact of coronary stent implantation on serum total PSA (tPSA) and free PSA (fPSA) levels.
This study involved 60 men who underwent coronary angiography for suspected coronary artery disease. Of these, 25 were diagnosed as having angiographically normal coronary arteries (Group 1) and 35 underwent coronary stent implantation (Group 2). Serum tPSA and fPSA levels and f/tPSA ratios were determined in all patients immediately before the intervention and 24 hours and 30 days after the procedure.
In Group 1, there was no statistically significant change in the values of tPSA, fPSA and f/tPSA ratio before and after coronary angiography (p >0.05). In Group 2, tPSA and fPSA values 24 hours after stent implantation were significantly higher than the values at the baseline (p <0.01), whereas f/tPSA ratio did not change (p >0.05). Compared with the baseline, there was no statistically significantly difference in the PSA values 30 days after stent implantation (p >0.05).
This study demonstrated that serum tPSA and fPSA levels are increased after coronary stent implantation, but f/tPSA ratio is not affected. The findings suggest that serum tPSA and fPSA levels should not be used for the diagnosis of prostate cancer during the first 30 days after coronary stenting.
前列腺特异抗原（PSA）是诊断和随访前列腺癌患者的最重要的生化标志物。近年来，已经描述了 PSA 水平与心血管状况之间的关系。然而，尚无研究调查过冠状动脉支架置入术后的 PSA 水平。
研究冠状动脉支架置入对血清总 PSA（tPSA）和游离 PSA（fPSA）水平的影响。
这项研究涉及 60 名因疑似冠状动脉疾病而行冠状动脉造影的男性。其中，25 名患者被诊断为冠状动脉造影正常（1 组），35 名患者接受了冠状动脉支架置入术（2 组）。所有患者在介入前、术后 24 小时和 30 天测定血清 tPSA 和 fPSA 水平和 f/tPSA 比值。
在 1 组中，冠状动脉造影前后 tPSA、fPSA 和 f/tPSA 比值无统计学显著变化（p>0.05）。在 2 组中，支架置入后 24 小时 tPSA 和 fPSA 值明显高于基线值（p<0.01），而 f/tPSA 比值没有变化（p>0.05）。与基线相比，支架置入后 30 天 PSA 值无统计学显著差异（p>0.05）。
本研究表明，冠状动脉支架置入后血清 tPSA 和 fPSA 水平升高，但 f/tPSA 比值不受影响。研究结果表明，在冠状动脉支架置入后 30 天内，不应使用血清 tPSA 和 fPSA 水平来诊断前列腺癌。
