Bioengineering Research Group, School of Engineering Sciences, University of Southampton, Southampton, SO17 1BJ, United Kingdom.
J Orthop Res. 2010 May;28(5):565-70. doi: 10.1002/jor.21040.
Clinical studies have revealed that aseptic loosening is the dominant cause of failure in total hip arthroplasty, particularly for the acetabular component. For a cemented polyethylene cup, failure is generally accompanied by the formation of fibrous tissue at the cement-bone interface. A variety of reasons for the formation of this tissue have been suggested, including osteolysis and mechanical overload at the cement-bone interface. In this study, a computational cement damage accumulation method was used to investigate the effect of polyethylene cup penetration, cement mantle thickness, and cement porosity on the number of cycles required to achieve mechanical fatigue failure of the cement mantle. Cup penetration was found to increase cement mantle stresses, resulting in a reduction in cement mantle fatigue life of 9% to 11% for a high cup penetration rate. The effect of using a thin (2 mm) over a thick (4 mm) cement mantle also reduced cement mantle fatigue life between 9% and 11%, and greatly raised cancellous bone stresses. Cement porosity was found to have very little effect on cement mantle fatigue life. Failure modes and cement stresses involved suggest that only extreme combinations of a thin cement mantle and high cup penetration may lead to mechanical failure of the cement mantle, thereby allowing wear debris access to the cement-bone interface. A thin cement mantle may also lead to the mechanical overload of the cement-bone interface. In this manner, the authors suggest that the mechanical factors may contribute to the failure mode of cemented polyethylene cups.
临床研究表明,无菌性松动是全髋关节置换术失效的主要原因,尤其是髋臼部件。对于粘结型聚乙烯杯,失效通常伴随着粘结-骨界面处纤维组织的形成。形成这种组织的原因有很多,包括粘结-骨界面处的溶骨和机械过载。在这项研究中,使用计算粘结损伤累积方法来研究聚乙烯杯穿透、水泥覆盖层厚度和水泥孔隙率对达到水泥覆盖层机械疲劳失效所需循环次数的影响。杯穿透增加了水泥覆盖层的应力,导致高杯穿透率下水泥覆盖层疲劳寿命减少 9%至 11%。使用较薄(2 毫米)的水泥覆盖层代替较厚(4 毫米)的水泥覆盖层,也会导致水泥覆盖层疲劳寿命减少 9%至 11%,同时大大增加松质骨的应力。水泥孔隙率对水泥覆盖层疲劳寿命几乎没有影响。失效模式和涉及的水泥应力表明,只有极薄的水泥覆盖层和高杯穿透的极端组合才可能导致水泥覆盖层的机械失效,从而使磨损碎片进入粘结-骨界面。薄的水泥覆盖层也可能导致粘结-骨界面的机械过载。通过这种方式,作者认为机械因素可能导致粘结型聚乙烯杯的失效模式。