Feng Rui, Li Ming-Huan, Kong Li, Shi Fang, Yang Guo-Ren, Yu Jin-Ming
Department of Radiotherapy, Shandong Cancer Hospital, Jinan 250117, China.
Zhonghua Zhong Liu Za Zhi. 2009 Jun;31(6):452-4.
To investigate the correlation between 18F-fluorodeoxyglucose (18FDG) uptake of primary lesions during PET-CT (positron emission tomography and computed tomography) examination and clinicopathological parameters such as the tumor length, depth of invasion, differentiation of the primary lesions and lymph node metastasis status in the patients with esophageal carcinoma.
From June 2004 to November 2006, 68 operable esophageal carcinoma patients were enrolled into this study, and all had a whole body 18FDG PET-CT scan before operation. The maximum standardized uptake value (SUVmax) of the primary lesions was measured. The tumor length, depth of invasion, differentiation of the primary lesions and lymph node metastasis status were determined by postoperative pathological examination. The correlation between the standardized uptake value (SUV) of primary lesions and the above mentioned clinicopathological parameters was analyzed.
The overall length of primary lesion was positively correlated with SUVmax (r=0.512, P=0.01). Depth of invasion was also positively correlated with SUVmax (r=0.860, P=0.000). There was a statistically significant difference in SUVmax between poorly differentiated group and moderately or well differentiated group (r=0.781, P=0.000), and also between the groups with or without lymph node metastasis (r=0.852, P=0.000).
The tumor length, depth of invasion and differentiation of the primary lesions of the esophageal carcinoma are all positively correlated with maximum standardized uptake value of 18FDG. The more poorly differentiated lesions show a higher 18FDG maximum standardized uptake value. The lesions with lymph node metastasis have also a significantly higher 18FDG maximum standardized uptake value than those without lymph node metastases.
探讨食管癌患者正电子发射断层显像及计算机断层扫描（PET-CT）检查时原发灶18F-氟脱氧葡萄糖（18FDG）摄取与肿瘤长度、浸润深度、原发灶分化程度及淋巴结转移状况等临床病理参数之间的相关性。
2004年6月至2006年11月，68例可手术切除的食管癌患者纳入本研究，所有患者术前均行全身18FDG PET-CT扫描。测量原发灶的最大标准化摄取值（SUVmax）。术后病理检查确定肿瘤长度、浸润深度、原发灶分化程度及淋巴结转移状况。分析原发灶标准化摄取值（SUV）与上述临床病理参数之间的相关性。
原发灶总长度与SUVmax呈正相关（r=0.512，P=0.01）。浸润深度也与SUVmax呈正相关（r=0.860，P=0.000）。低分化组与中分化或高分化组之间SUVmax有统计学显著差异（r=0.781，P=0.000），有淋巴结转移组与无淋巴结转移组之间也有差异（r=0.852，P=0.000）。
食管癌原发灶的肿瘤长度、浸润深度及分化程度均与18FDG最大标准化摄取值呈正相关。分化越差的病灶18FDG最大标准化摄取值越高。有淋巴结转移的病灶18FDG最大标准化摄取值也显著高于无淋巴结转移的病灶。
