Soler C, Poveda B, Pastor-Anglada M, Soley M
Department de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
Biochim Biophys Acta. 1991 Jan 31;1091(2):193-6. doi: 10.1016/0167-4889(91)90061-2.
It was found that EGF decreased both the basal- and the glucagon-stimulated gluconeogenesis from lactate alone or from a high lactate/pyruvate ratio and that it enhanced both the basal- and the glucagon-inhibited glucose synthesis from pyruvate alone or from a low lactate/pyruvate ratio. These findings demonstrate that the effect of both EGF and glucagon on glucose production by isolated hepatocytes depends on the red-ox state of the substrate.
