Cengel-Kültür S Ebru, Cöp Esra, Kara Ateş, Cengiz Ali Bülent, Uludağ Ali Kerem, Unal Fatih
Department of Child and Adolescent Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 2009 Jul-Aug;51(4):317-24.
The aim of this study was to test if children with group A beta hemolytic streptococcal infection (GABHS) are more likely to develop neuropsychiatric symptoms or the syndrome of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS) compared to children with GABHS-negative throat cultures. Children aged 8 to 12 years (n = 81) with upper respiratory tract infection were assessed with the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version, Children's Yale Brown Obsession Compulsion Scale, Yale Global Tic Severity Scale, Child Behavior Checklist for Ages 4-18, Conners Parent Rating Scale, and State-Trait Anxiety Inventory for Children at baseline and six weeks later. One case of PANDAS was diagnosed and no other differences were observed between groups and time points. It was suggested that GABHS infection may be a triggering factor for PANDAS in some genetically prone individuals.
本研究的目的是检验与A组β溶血性链球菌感染（GABHS）咽拭子培养阴性的儿童相比，患有GABHS感染的儿童是否更有可能出现神经精神症状或小儿自身免疫性神经精神障碍伴链球菌感染（PANDAS）综合征。对8至12岁（n = 81）患有上呼吸道感染的儿童，在基线时以及六周后，使用学龄儿童情感障碍和精神分裂症量表（目前和终生版）、儿童耶鲁布朗强迫量表、耶鲁全球抽动严重程度量表、4至18岁儿童行为清单、康纳斯父母评定量表以及儿童状态-特质焦虑量表进行评估。诊断出1例PANDAS病例，且在组间和时间点之间未观察到其他差异。研究表明，在一些具有遗传易感性的个体中，GABHS感染可能是PANDAS的触发因素。
