Department of Anesthesiology, Kansai Medical University, Osaka, Japan.
Immunopharmacol Immunotoxicol. 2009;31(1):150-7. doi: 10.1080/08923970802590415.
Dendritic cell-based vaccines are useful for enhancing antitumor immunity. It has been suggested that propofol, an intravenous anesthetic, can enhance antitumor immunity in mice. We tested vaccine efficacy for eliciting antitumor immunity, using dendritic cells differentiated from bone marrow cells in the presence of propofol. Propofol-differentiated (but not control vehicle-differentiated) dendritic cells significantly delayed the growth of B16 melanoma in vivo. In vitro cytotoxic T cell activity was not affected by propofol. However, natural killer cell activity in mice vaccinated with dendritic cells differentiated in propofol was significantly upregulated, compared to unvaccinated mice.
树突状细胞疫苗可用于增强抗肿瘤免疫。有研究表明，静脉麻醉药异丙酚可增强小鼠的抗肿瘤免疫。我们测试了使用异丙酚诱导分化的骨髓细胞来源的树突状细胞作为疫苗诱导抗肿瘤免疫的功效。与对照组（用对照溶剂分化的树突状细胞）相比，异丙酚分化的树突状细胞（而非对照溶剂分化的树突状细胞）显著延迟了 B16 黑色素瘤在体内的生长。异丙酚对体外细胞毒性 T 细胞活性没有影响。然而，与未接种疫苗的小鼠相比，用异丙酚分化的树突状细胞接种的小鼠的自然杀伤细胞活性显著上调。
