Ueyama Yukie, Lerche Phillip, Eppler C Mark, Muir William W
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Am J Vet Res. 2009 Dec;70(12):1459-64. doi: 10.2460/ajvr.70.12.1459.
OBJECTIVE-To determine the effects of IV administration of perzinfotel and a perzinfotel-fentanyl combination on the minimum alveolar concentration (MAC) of isoflurane in dogs. ANIMALS-6 healthy sexually intact Beagles (3 males and 3 females). PROCEDURES-All dogs were instrumented with a telemetry device for continuous monitoring of heart rate, arterial blood pressure, and core body temperature (at a femoral artery). Dogs were anesthetized with propofol (6 mg/kg, IV) and isoflurane. Isoflurane MAC values were determined in 3 experiments in each dog, separated by at least 7 days, before (baseline) and after the following treatments: no treatment (anesthetic only), perzinfotel (20 mg/kg, IV), fentanyl (5 microg/kg bolus, IV, followed by a continuous IV infusion at 0.15 microg/kg/min), and a fentanyl-perzinfotel combination (20 mg of perzinfotel/kg, IV, plus the fentanyl infusion). Bispectral index and oxygen saturation as measured by pulse oximetry were also monitored throughout anesthesia. RESULTS-Without treatment, the mean +/- SD isoflurane MAC for all 6 dogs was 1.41 +/- 0.10%. Baseline MAC was 1.42 +/- 0.08%. Intravenous administration of perzinfotel, fentanyl, and the perzinfotel-fentanyl combination significantly decreased the MAC by 39%, 35%, and 66%, respectively. Perzinfotel and perzinfotel-fentanyl administration yielded significant increases in the bispectral index. Mean, systolic, and diastolic arterial blood pressures significantly increased from baseline values when perzinfotel was administered. Systolic arterial blood pressure significantly increased from the baseline value when perzinfotel-fentanyl was administered. No adverse effects were detected. CONCLUSIONS AND CLINICAL RELEVANCE-IV administration of perzinfotel, fentanyl, or a perzinfotel-fentanyl combination reduced isoflurane MAC in dogs and increased arterial blood pressure.
目的——确定静脉注射泊津托泰以及泊津托泰与芬太尼联合用药对犬异氟烷最低肺泡浓度（MAC）的影响。动物——6只健康、性成熟的比格犬（3只雄性，3只雌性）。方法——所有犬均植入遥测装置，用于连续监测心率、动脉血压和核心体温（股动脉处）。犬用丙泊酚（6mg/kg，静脉注射）和异氟烷麻醉。在每只犬的3次实验中测定异氟烷MAC值，每次实验间隔至少7天，分别在以下处理之前（基线）和之后进行：未处理（仅麻醉）、泊津托泰（20mg/kg，静脉注射）、芬太尼（5μg/kg静脉推注，随后以0.15μg/kg/min持续静脉输注）以及芬太尼 - 泊津托泰联合用药（20mg泊津托泰/kg，静脉注射，加芬太尼输注）。在整个麻醉过程中还监测脑电双频指数和通过脉搏血氧饱和度测定法测得的血氧饱和度。结果——未处理时，所有6只犬的平均±标准差异氟烷MAC为1.41±0.10%。基线MAC为1.42±0.08%。静脉注射泊津托泰、芬太尼以及泊津托泰 - 芬太尼联合用药分别使MAC显著降低39%、35%和66%。注射泊津托泰和泊津托泰 - 芬太尼后脑电双频指数显著升高。注射泊津托泰时，平均、收缩压和舒张压动脉血压较基线值显著升高。注射泊津托泰 - 芬太尼时，收缩压动脉血压较基线值显著升高。未检测到不良反应。结论及临床意义——静脉注射泊津托泰、芬太尼或泊津托泰 - 芬太尼联合用药可降低犬异氟烷MAC并升高动脉血压。
