动脉自旋标记显示，焦点杏仁核谷氨酸能激动剂输注会导致快速弥漫性脑激活。
Arterial spin labeling demonstrates that focal amygdalar glutamatergic agonist infusion leads to rapid diffuse cerebral activation.
机构信息
MRI Research Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
出版信息
Acta Neurol Scand. 2010 Mar;121(3):209-16. doi: 10.1111/j.1600-0404.2009.01188.x. Epub 2009 Nov 25.
OBJECTIVES
To investigate acute effects of intra-amygdalar excitatory amino acid administration on blood flow, relaxation time and apparent diffusion coefficient in rat brain.
MATERIALS AND METHODS
Several days after MR-compatible cannula placement in right basolateral amygdala, anesthetized rats were imaged at 7 T. Relative cerebral blood flow (CBF) was measured before and 60 min after infusion of 10 nmol KA, cAMPA, ATPA, or normal saline using arterial spin labeling. Quantitative T(2) and diffusion-weighted images were acquired. rCBF, T(2) and ADC values were evaluated in bilateral basolateral amygdala, hippocampus, basal ganglia, frontal and parietal regions.
RESULTS
KA led to the highest, and ATPA lowest bilateral rCBF increases. Time courses varied among drugs. T(2) for KA and AMPA was higher while ADC was lower for KA.
CONCLUSIONS
Intra-amygdalar injection of GluR agonists evoked bilateral seizure activity and increased rCBF, greater for KA and AMPA than selective ATPA GluR5 activation.
目的
研究内嗅杏仁核兴奋性氨基酸给药对大鼠脑血流、弛豫时间和表观扩散系数的急性影响。
材料与方法
在右基底外侧杏仁核中进行了磁共振兼容套管放置数天后，在 7T 下对麻醉大鼠进行成像。使用动脉自旋标记法在灌流 10nmolKA、CAMPA、ATPA 或生理盐水之前和之后 60 分钟测量相对脑血流量（rCBF）。采集定量 T2 和扩散加权图像。在双侧基底外侧杏仁核、海马体、基底神经节、额叶和顶叶区域评估 rCBF、T2 和 ADC 值。
结果
KA 导致双侧 rCBF 增加最高，而 ATPA 导致双侧 rCBF 增加最低。药物之间的时间过程有所不同。KA 和 AMPA 的 T2 较高，而 KA 的 ADC 较低。
结论
内嗅杏仁核内注射 GluR 激动剂引起双侧癫痫发作，并增加 rCBF，KA 和 AMPA 的作用大于选择性 ATPA GluR5 激活。
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