人类端粒 G-四链体：DNA 和 RNA 序列的结构。

Human telomeric G-quadruplex: structures of DNA and RNA sequences.

机构信息

Division of Physics & Applied Physics, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore.

出版信息

FEBS J. 2010 Mar;277(5):1107-17. doi: 10.1111/j.1742-4658.2009.07464.x. Epub 2009 Nov 27.

DOI:10.1111/j.1742-4658.2009.07464.x

PMID:19951353

Abstract

Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This minireview describes the structural diversity or conservation of DNA and RNA human telomeric G-quadruplexes, discusses structural views on targeting these G-quadruplexes and presents some future challenges for structural studies.

摘要

端粒在细胞衰老和癌症中起着重要作用。人类端粒 DNA 和 RNA G-丰富序列能够形成一种四链结构，称为 G-四链体。这种结构可能对端粒生物学很重要，也是药物设计的一个很好的靶点。这篇综述描述了 DNA 和 RNA 人类端粒 G-四链体的结构多样性或保守性，讨论了针对这些 G-四链体的结构观点，并提出了一些未来结构研究的挑战。