Department of Endocrinology, Diabetology, and Rheumatology, Heinrich Heine University, 40225 Düsseldorf, Germany.
Arthritis Res Ther. 2009;11(6):256. doi: 10.1186/ar2847. Epub 2009 Nov 23.
Synovial biopsies, gained either by blind needle biopsy or minimally invasive arthroscopy, offer additional information in certain clinical situations where routine assessment has not permitted a certain diagnosis. In research settings, synovial histology and modern applications of molecular biology increase our insight into pathogenesis and enable responses to treatment with new therapeutic agents to be assessed directly at the pathophysiological level. This review focuses on the diagnostic usefulness of synovial biopsies in the light of actual developments.
滑膜活检可以通过盲检或微创关节镜检查获得，在常规评估无法确定明确诊断的某些临床情况下，提供了更多信息。在研究环境中，滑膜组织学和分子生物学的现代应用增加了我们对发病机制的认识，并使我们能够直接在病理生理学水平上评估新治疗药物的治疗反应。本综述根据实际进展，重点讨论了滑膜活检的诊断价值。
