Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai 200233, China.
Chin Med J (Engl). 2009 Nov 5;122(21):2530-3.
Vaspin is a newly-identified adipocytokine related to obesity and insulin sensitivity. However, its pathophysiologic role in humans remains largely unknown. The aim of our study was to investigate the relationship between serum vaspin level and glucose metabolism or obesity in Chinese adults.
A total of 123 subjects, including 84 subjects with normal glucose tolerance (NGT) and 39 subjects with diabetes, were enrolled in this study. Anthropometric parameters, abdominal fat areas, plasma glucose concentration, serum insulin, lipids, and vaspin level were measured in each participant.
Serum vaspin concentration was significantly higher in diabetic patients than that in NGT subjects (592 (438 - 695) pg/ml vs 380 (294 - 517) pg/ml, P = 0.020) in women. In all participants, age, fasting plasma glucose concentration (FPG), 2-hour post-load plasma glucose (PG2h), hemoglobin A1c (HbA1c) and high-density lipoprotein cholesterol (HDL-c) significantly increased from the lower tertile to the higher tertile of vaspin. Univariate linear regression analyses revealed that vaspin level was only positively correlated with age (beta = 0.340, P = 0.002) in NGT subjects. And vaspin was positively associated with FPG (beta = 0.365, P = 0.023), PG2h (beta = 0.526, P = 0.001), HbA1c (beta = 0.388, P = 0.016), and HDL-c (beta = 0.353, P = 0.027), while negatively with homeostasis model assessment of beta cell function (HOMA-beta) (beta = -0.361, P = 0.024) in diabetic patients. In stepwise multivariate regression analyses, age was independently associated with circulating vaspin in NGT subjects, whereas PG2h was an independent predictor of vaspin in diabetic patients. In addition, there was no significant difference of serum vaspin level between men and women. And no significant correlations between vaspin and body fat indexes were detected.
Serum vaspin level is higher in diabetic patients than that in NGT subjects in women. Age predicts serum vaspin level in NGT subjects, while PG2h is independently associated with vaspin in diabetic patients.
Vaspin 是一种新发现的与肥胖和胰岛素敏感性相关的脂肪细胞因子。然而，其在人体中的病理生理作用仍知之甚少。我们的研究旨在探讨中国成年人血清 vaspin 水平与葡萄糖代谢或肥胖之间的关系。
本研究共纳入 123 例受试者，其中 84 例糖耐量正常（NGT），39 例糖尿病。每位受试者均测量了体重指数、腹部脂肪面积、血糖浓度、血清胰岛素、血脂和 vaspin 水平。
在女性中，糖尿病患者血清 vaspin 浓度显著高于 NGT 组（592（438-695）pg/ml 比 380（294-517）pg/ml，P=0.020）。在所有参与者中，年龄、空腹血糖浓度（FPG）、餐后 2 小时血糖（PG2h）、糖化血红蛋白（HbA1c）和高密度脂蛋白胆固醇（HDL-c）均从 vaspin 低三分位到高三分位显著升高。单因素线性回归分析显示，在 NGT 组中，vaspin 水平仅与年龄呈正相关（β=0.340，P=0.002）。此外，vaspin 与 FPG（β=0.365，P=0.023）、PG2h（β=0.526，P=0.001）、HbA1c（β=0.388，P=0.016）和 HDL-c（β=0.353，P=0.027）呈正相关，与胰岛β细胞功能的稳态模型评估（HOMA-β）（β=-0.361，P=0.024）呈负相关。多元逐步回归分析显示，在 NGT 组中，年龄是循环 vaspin 的独立相关因素，而 PG2h 是糖尿病患者 vaspin 的独立预测因素。此外，血清 vaspin 水平在男性和女性之间无显著差异，且与体脂指数无显著相关性。
在女性中，糖尿病患者的血清 vaspin 水平高于 NGT 组。在 NGT 组中，年龄可预测血清 vaspin 水平，而 PG2h 与糖尿病患者的 vaspin 独立相关。
