Bandino Justin P, Wohltmann Wendi E, Bray David W, Hoover Aaron Z
Transitional intern, San Antonio Military Medical Center (SAMMC), San Antonio, Texas, USA.
Dermatol Online J. 2009 Nov 15;15(11):4.
A fixed drug eruption (FDE) is a cutaneous reaction to an ingested drug that recurs at the same site each time the offending drug is taken. Clinical diagnosis may be difficult as patients often do not consider over-the-counter medications or supplements as part of their reported medication list. In addition, patients may take the offending medication so infrequently that the eruption does not occur often enough to easily allow them to deduce the association. The most common offending agents include anti-microbials, non-steroidal anti-inflammatory drugs (NSAIDs), and anti-epileptics. Fixed drug eruptions classically present as a single, sharply demarcated, round erythematous patch or plaque, occasionally with localized bullae. Generalized bullous FDEs, however, are relatively rare and can be confused with Stevens-Johnson Syndrome. We present a case of naproxen-induced generalized bullous FDE in a 50-year-old woman.
固定性药疹（FDE）是一种对摄入药物的皮肤反应，每次服用致病药物时都会在同一部位复发。临床诊断可能很困难，因为患者通常不将非处方药物或补充剂视为其报告的用药清单的一部分。此外，患者服用致病药物的频率可能很低，以至于皮疹不常出现，难以让他们轻易推断出这种关联。最常见的致病药物包括抗菌药物、非甾体抗炎药（NSAIDs）和抗癫痫药。固定性药疹典型表现为单个、边界清晰的圆形红斑或斑块，偶尔伴有局部水疱。然而，泛发性大疱性固定性药疹相对少见，可能会与史蒂文斯-约翰逊综合征混淆。我们报告一例50岁女性因萘普生引起的泛发性大疱性固定性药疹。
