Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2009 Dec;25(12):640-6. doi: 10.1016/S1607-551X(09)70569-8.
In this study, we investigated the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) Tyr705 and suppressor of cytokine signaling 3 (SOCS3) in urothelial carcinoma (UC). p-STAT3 (Tyr705) and SOCS3 were analyzed by immunohistochemistry using tissue microarray and Western blotting. Our results showed that p-STAT3 (Tyr705) was frequently detected in high-grade and infiltrating UC. However, there was no difference in p-STAT3 (Tyr705) staining between UC of the upper and lower urinary tracts. In addition, there was no significant correlation between expression of SOCS3 and histological differentiation and invasiveness of UC. These findings suggest that overexpression of p-STAT3 (Tyr705) occurs in UC, and that pathways other than SOCS3 may contribute to its activation in this cancer.
在这项研究中，我们调查了磷酸化信号转导子和转录激活子 3（p-STAT3）Tyr705 和细胞因子信号转导抑制因子 3（SOCS3）在尿路上皮癌（UC）中的表达。使用组织微阵列和 Western blot 分析了 p-STAT3（Tyr705）和 SOCS3。我们的结果表明，p-STAT3（Tyr705）在高级别和浸润性 UC 中频繁检测到。然而，上尿路和下尿路 UC 之间的 p-STAT3（Tyr705）染色没有差异。此外，SOCS3 的表达与 UC 的组织学分化和浸润性之间没有显著相关性。这些发现表明，p-STAT3（Tyr705）在 UC 中过度表达，并且在这种癌症中其激活可能涉及 SOCS3 以外的途径。
