College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.
Biol Pharm Bull. 2009 Dec;32(12):2057-60. doi: 10.1248/bpb.32.2057.
Hypoxia, which is intimately associated with the biology of breast carcinomas, modulates the level of estrogen receptor (ER) alpha expression and transactivation. We investigated the effect of blocking ER degradation on ERalpha-mediated transactivation under hypoxic conditions using the proteasome inhibitor MG132. Pretreatment with MG132 blocked hypoxia-induced degradation of ERalpha protein. Our data imply that ERalpha proteasomal inhibition is linked to receptor transactivation under hypoxia.
缺氧与乳腺癌的生物学密切相关，调节雌激素受体 (ER)α 的表达和转录激活水平。我们使用蛋白酶体抑制剂 MG132 研究了阻断 ER 降解对缺氧条件下 ERα 介导的转录激活的影响。MG132 预处理可阻断缺氧诱导的 ERα 蛋白降解。我们的数据表明，ERα 蛋白酶体抑制与缺氧下受体的转录激活有关。
