Advanced Materials Institute, Fukuoka University, 8-19-1 Nanakuma, Fukuoka, 814-0180, Japan.
Biol Pharm Bull. 2009 Dec;32(12):2065-7. doi: 10.1248/bpb.32.2065.
The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of immobility by THC. We investigated the effect of THC on levels of stress hormone corticosterone under non-stress and forced swim-stress conditions. THC did not affect plasma corticosterone levels under non-stress conditions. However, THC, together with forced swim-stress, significantly increased plasma corticosterone levels. This effect was inhibited by O-2050. This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB(1) receptor, thereby increasing the risk of depression.
本研究旨在确定大麻二酚（THC）对压力易感性的影响。我们报告说，THC 显著延长了强迫游泳应激期间的不动时间。选择性大麻素 CB1 受体拮抗剂 O-2050 显著降低了 THC 对不动时间的增强作用。我们研究了 THC 在非应激和强迫游泳应激条件下对应激激素皮质酮水平的影响。THC 不影响非应激条件下的血浆皮质酮水平。然而，THC 与强迫游泳应激一起，显著增加了血浆皮质酮水平。这种作用被 O-2050 抑制。这一证据表明，THC 在应激条件下，通过 CB1 受体增强下丘脑-垂体-肾上腺轴对压力的敏感性，从而增加患抑郁症的风险。
