Miyachi Kanako, Nakao Masahiro, Kurokawa Hisashi, Tomida Mayu, Kamino Shinichiro, Moriyama Kenzo, Yamaguchi Takako, Fujita Yoshikazu
Department of Hospital Pharmacy School of Medicine, Kinki University, Osaka-Sayama, Japan.
Yakugaku Zasshi. 2009 Dec;129(12):1551-8. doi: 10.1248/yakushi.129.1551.
We examined a simple screening method for judging the complex formation between a drug and aluminum(III) on a spot plate. As few drug had color reaction by basing on the binary complex formation of drug-aluminum(III), the ternary complex formation of drug-aluminum(III)-dye was studied this time using 50 kinds of drugs. The dyes used were Chromazurol S and Erythrosin. As a result, in the drug that the complex formation with aluminum(III) was assumed, a remarkable coloration difference was recognized in comparison with the blank prepared under the same conditions. The proposed simple screening method should be very useful for judging instantly the complex formation between a drug and aluminum(III).
我们研究了一种在点滴板上判断药物与铝（III）之间络合物形成的简单筛选方法。由于基于药物 - 铝（III）二元络合物形成时很少有药物产生颜色反应，此次使用50种药物研究了药物 - 铝（III） - 染料的三元络合物形成。所使用的染料为铬天青S和赤藓红。结果，在假定与铝（III）形成络合物的药物中，与在相同条件下制备的空白相比，观察到了明显的颜色差异。所提出的这种简单筛选方法对于即时判断药物与铝（III）之间的络合物形成应该非常有用。
