孕期疾病和细菌性阴道病与宫内 HIV-1 传播有关。
Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission.
机构信息
Department of Medicine, University of Washington, 325 Ninth Avenue, Box 359909, Seattle, WA 98104, USA.
出版信息
AIDS. 2010 Jan 2;24(1):153-5. doi: 10.1097/QAD.0b013e32832326d8.
Abstract
HIV-1 transmission in utero accounts for 20-30% of vertical transmission events in breast-feeding populations. In a prospective study of 463 HIV-1-infected mothers and infants, illness during pregnancy was associated with 2.6-fold increased risk of in-utero HIV-1 transmission [95% confidence interval (CI) 1.2-5.8] and bacterial vaginosis with a three-fold increase (95% CI 1.0-7.0) after adjusting for maternal HIV-1 viral load. Interventions targeting these novel risk factors could lead to more effective prevention of transmission during pregnancy.
摘要
HIV-1 经母婴垂直传播在母乳喂养人群中占 20-30%。在对 463 例 HIV-1 感染母婴的前瞻性研究中，母亲孕期患病会使 HIV-1 经母婴垂直传播的风险增加 2.6 倍[95%置信区间（CI）1.2-5.8]，细菌性阴道病使风险增加 3 倍[95%CI 1.0-7.0]，但校正 HIV-1 病毒载量后，这两种因素的影响仍有统计学意义。针对这些新的危险因素进行干预，可能会更有效地预防孕期母婴垂直传播。
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