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1
Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials.在埃塞俄比亚、印度和乌干达，对婴儿延长奈韦拉平用药至6周龄以预防通过母乳喂养传播艾滋病毒：三项随机对照试验的分析
Lancet. 2008 Jul 26;372(9635):300-13. doi: 10.1016/S0140-6736(08)61114-9.
2
Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission.延长抗逆转录病毒预防措施以减少母乳中HIV-1的传播。
N Engl J Med. 2008 Jul 10;359(2):119-29. doi: 10.1056/NEJMoa0801941. Epub 2008 Jun 4.
3
Reducing the risk of mother-to-child human immunodeficiency virus transmission: past successes, current progress and challenges, and future directions.降低母婴传播人类免疫缺陷病毒的风险：过去的成功、当前的进展与挑战以及未来的方向
Am J Obstet Gynecol. 2007 Sep;197(3 Suppl):S3-9. doi: 10.1016/j.ajog.2007.06.048.
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Biological mechanisms of vertical human immunodeficiency virus (HIV-1) transmission.人类免疫缺陷病毒1型（HIV-1）垂直传播的生物学机制。
Rev Med Virol. 2007 Nov-Dec;17(6):381-403. doi: 10.1002/rmv.543.
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Herpes simplex virus type 2 and risk of intrapartum human immunodeficiency virus transmission.2型单纯疱疹病毒与产时人类免疫缺陷病毒传播风险
Obstet Gynecol. 2007 Feb;109(2 Pt 1):403-9. doi: 10.1097/01.AOG.0000251511.27725.5c.
6
A phase III clinical trial of antibiotics to reduce chorioamnionitis-related perinatal HIV-1 transmission.一项关于使用抗生素降低与绒毛膜羊膜炎相关的围产期HIV-1传播的III期临床试验。
AIDS. 2006 Jun 12;20(9):1313-21. doi: 10.1097/01.aids.0000232240.05545.08.
7
Acute and chronic chorioamnionitis and the risk of perinatal human immunodeficiency virus-1 transmission.急性和慢性绒毛膜羊膜炎与围产期人类免疫缺陷病毒1型传播风险
Am J Obstet Gynecol. 2006 Jan;194(1):174-81. doi: 10.1016/j.ajog.2005.06.081.

孕期疾病和细菌性阴道病与宫内 HIV-1 传播有关。

Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission.

机构信息

Department of Medicine, University of Washington, 325 Ninth Avenue, Box 359909, Seattle, WA 98104, USA.

出版信息

AIDS. 2010 Jan 2;24(1):153-5. doi: 10.1097/QAD.0b013e32832326d8.

DOI:10.1097/QAD.0b013e32832326d8
PMID:19952542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2788745/
Abstract

HIV-1 transmission in utero accounts for 20-30% of vertical transmission events in breast-feeding populations. In a prospective study of 463 HIV-1-infected mothers and infants, illness during pregnancy was associated with 2.6-fold increased risk of in-utero HIV-1 transmission [95% confidence interval (CI) 1.2-5.8] and bacterial vaginosis with a three-fold increase (95% CI 1.0-7.0) after adjusting for maternal HIV-1 viral load. Interventions targeting these novel risk factors could lead to more effective prevention of transmission during pregnancy.

摘要

HIV-1 经母婴垂直传播在母乳喂养人群中占 20-30%。在对 463 例 HIV-1 感染母婴的前瞻性研究中，母亲孕期患病会使 HIV-1 经母婴垂直传播的风险增加 2.6 倍[95%置信区间（CI）1.2-5.8]，细菌性阴道病使风险增加 3 倍[95%CI 1.0-7.0]，但校正 HIV-1 病毒载量后，这两种因素的影响仍有统计学意义。针对这些新的危险因素进行干预，可能会更有效地预防孕期母婴垂直传播。