Department of Neurology, Faculty of Medicine, Maltepe University, Istanbul, Turkey.
J Clin Neurophysiol. 2009 Dec;26(6):454-7. doi: 10.1097/WNP.0b013e3181c29914.
Alterations in blink reflex excitability may occur in the contralateral side (CLS) and in the symptomatic side after peripheral facial palsy (PFP). In this study, the alterations of blink reflex in CLS were evaluated in cases with PFP who showed "three different types" of recovery. For this purpose, the R2 response area and recovery curve of the blink reflex were evaluated. The study included 51 patients suffering from PFP and 20 age- and sex-matched healthy controls. Cases with PFP were divided into three groups: patients with PFP with partially cured and accompanied by synkinesis (postfacial syndrome), patients with PFP with residual weakness, and patients who suffered from recurrent PFP. All three groups' R2 values of CLS were compared with the values of controls and patients who had synkinesis. The CLS of all three groups' R2 area values were found to be significantly higher when compared with controls. These values were found to be highest in patients who suffered from recurrent PFP. Hyperexcitability occurs in CLS after PFP and this is highest in patients who suffer from recurrent PFP. It suggested that the contralateral reorganization caused by peripheral nerve damage correlates with the severity of the lesion and the recurrence of axon damage enhances the excitability of the reflex cycle, which affects the contralateral facial nucleus.
在周围性面瘫(PFP)后,眨眼反射兴奋性的改变可能发生在对侧(CLS)和症状侧。在这项研究中,评估了表现出“三种不同类型”恢复的 PFP 患者 CLS 眨眼反射的变化。为此,评估了眨眼反射的 R2 反应面积和恢复曲线。该研究包括 51 名患有 PFP 的患者和 20 名年龄和性别匹配的健康对照者。将 PFP 患者分为三组:伴有面肌痉挛(面瘫后综合征)和部分治愈的 PFP 患者、残留肌无力的 PFP 患者和患有复发性 PFP 的患者。将所有三组的 CLS 的 R2 值与对照组和患有面肌痉挛的患者的 R2 值进行比较。与对照组相比,所有三组的 CLS 的 R2 面积值均明显更高。在患有复发性 PFP 的患者中,这些值最高。在 PFP 后 CLS 出现兴奋性过高,在患有复发性 PFP 的患者中最为明显。这表明,周围神经损伤引起的对侧重组与病变的严重程度和轴突损伤的复发有关,增强了反射周期的兴奋性,从而影响了对侧面核。