Polimeno L, Azzarone A, Dell'Aquila P, Amoruso C, Barone M, Angelini A, Van Thiel D H, Francavilla A
Department of Gastroenterology, University of Bari, Italy.
Dig Dis Sci. 1991 Mar;36(3):289-92. doi: 10.1007/BF01318198.
Ornithine decarboxylase (ODC) and thymidine kinase (TK) are enzymes important for DNA synthesis, a process that is critical for cell renewal and regeneration. As such, they already have been used as surrogate markers of regeneration in tissue. In the present study, the activity of these two enzymes in plasma of rats and regenerating hepatic tissue following a 70% hepatectomy were determined. The results demonstrate that the changes in these enzyme activities in plasma reflect the changes obtained in the liver tissue. Thus, blood levels of ODC and TK can be used as a less invasive and nondestructive means of monitoring the regenerative response of the liver and possibly other tissues.
鸟氨酸脱羧酶（ODC）和胸苷激酶（TK）是对DNA合成很重要的酶，DNA合成是细胞更新和再生的关键过程。因此，它们已被用作组织再生的替代标志物。在本研究中，测定了大鼠血浆以及70%肝切除术后再生肝组织中这两种酶的活性。结果表明，血浆中这些酶活性的变化反映了肝组织中的变化。因此，ODC和TK的血液水平可作为一种侵入性较小且非破坏性的手段，用于监测肝脏以及可能其他组织的再生反应。
