Pediatric Endocrinology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Curr Opin Endocrinol Diabetes Obes. 2010 Feb;17(1):25-30. doi: 10.1097/MED.0b013e328334f041.
Regulation of calcium and phosphorus levels in the fetus and neonate is critical for proper bone development and mineralization.
Parathyroid hormone-related peptide plays an important role in transferring calcium across the placenta into the fetal circulation. In contrast, the factors controlling placental phosphate transport have not yet been explored, and numerous studies have indicated that maternal and childhood vitamin D deficiency continues to be a significant clinical concern.
The molecular basis for mineral ion homeostasis in the fetus and child remains incompletely understood. More attention must be paid to identifying and treating maternal, neonatal, and childhood vitamin D deficiency.
调节胎儿和新生儿体内钙磷水平对骨骼正常发育和矿化至关重要。
甲状旁腺激素相关肽在将钙从胎盘转运到胎儿循环中发挥着重要作用。相比之下，控制胎盘磷酸盐转运的因素尚未得到探索，许多研究表明，母亲和儿童维生素 D 缺乏仍然是一个重大的临床关注点。
胎儿和儿童体内矿物质离子稳态的分子基础仍不完全清楚。必须更加重视识别和治疗母亲、新生儿和儿童的维生素 D 缺乏症。
